Abstract
Fluorescent carbon dots (CDs) have been extensively utilized as responsive drug nanocarriers to deliver anticancer agents, owing to their facile preparation, excellent water solubility, good photostability, and high quantum yield. Herein, we summarize the protocols for the synthesis and application of responsive CDs toward anticancer drug delivery both in vitro and in vivo. Specially, this chapter includes the preparation and structural characterization of CDs and anticancer prodrug-loaded CDs, in vitro anticancer drug release, in vitro and in vivo fluorescence imaging, and toxicity studies.
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Acknowledgments
The authors thank the financial support from the Singapore National Research Foundation Investigatorship (NRF-NRFI2018-03).
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Feng, T., Zhao, Y. (2019). Preparation of Responsive Carbon Dots for Anticancer Drug Delivery. In: Weissig, V., Elbayoumi, T. (eds) Pharmaceutical Nanotechnology. Methods in Molecular Biology, vol 2000. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9516-5_15
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DOI: https://doi.org/10.1007/978-1-4939-9516-5_15
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