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A Blood Flow Modeling Framework for Stroke Treatments

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High Performance Computing for Drug Discovery and Biomedicine

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2716))

Abstract

Circulatory models can significantly help develop new ways to alleviate the burden of stroke on society. However, it is not always easy to know what hemodynamics conditions to impose on a numerical model or how to simulate porous media, which ineluctably need to be addressed in strokes. We propose a validated open-source, flexible, and publicly available lattice-Boltzmann numerical framework for such problems and present its features in this chapter. Among them, we propose an algorithm for imposing pressure boundary conditions. We show how to use the method developed by Walsh et al. (Comput Geosci 35(6):1186–1193, 2009) to simulate the permeability law of any porous medium. Finally, we illustrate the features of the framework through a thrombolysis model.

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Acknowledgements

This research has been developed under the umbrella of the CompBioMed Consortium and the INSIST project [37], which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 777072.

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Authors and Affiliations

  1. Scientific and Parallel Computing Group, Computer Science Department, University of Geneva, Carouge, Switzerland

    Remy Petkantchin, Franck Raynaud & Bastien Chopard

  2. Laboratory of Experimental Medicine (ULB222), Faculty of Medicine, Université libre de Bruxelles, CHU de Charleroi, Charleroi, Belgium

    Karim Zouaoui Boudjeltia

Authors
  1. Remy Petkantchin
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  2. Franck Raynaud
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  3. Karim Zouaoui Boudjeltia
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  4. Bastien Chopard
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Correspondence to Bastien Chopard .

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  1. In Silico Research and Development, Evotec UK Ltd, Abingdon, UK

    Alexander Heifetz

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Petkantchin, R., Raynaud, F., Boudjeltia, K.Z., Chopard, B. (2024). A Blood Flow Modeling Framework for Stroke Treatments. In: Heifetz, A. (eds) High Performance Computing for Drug Discovery and Biomedicine. Methods in Molecular Biology, vol 2716. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3449-3_17

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  • DOI: https://doi.org/10.1007/978-1-0716-3449-3_17

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3448-6

  • Online ISBN: 978-1-0716-3449-3

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