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Voxel-Based Lesion Symptom Map**

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Lesion-to-Symptom Map**

Part of the book series: Neuromethods ((NM,volume 180))

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Abstract

Lesion-behavior map** has been used for over 200 years as a method for understanding the relationship between distinct brain regions and the functions they subserve. A relatively recent advancement in this area has been the development of voxel-based statistical techniques that allow for whole-brain analysis of lesion data in relation to specific behaviors and symptoms in neurologic patients. In this chapter, we describe current best practices for one of these techniques, voxel-based lesion-symptom map** (VLSM), and review key studies in the literature that have made use of this methodology to advance our understanding of brain-behavior relationships. Best practices include rigorous statistical correction for family-wise error, covarying for potentially confounding variables, and limiting interpretation to brain regions with sufficient statistical power. In some cases, VLSM has confirmed earlier findings of lesion-behavioral correlates from small group and case studies, but in other cases, VLSM findings have challenged classical models of brain-behavior relationships. Together with newer multivariate techniques, VLSM is a powerful new tool that can be applied to large datasets to further our understanding of the relationship between brain and behavior.

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Change history

  • 06 October 2022

    This chapter was mistakenly published with mistake in chapter 5. The Figure 4 was incorrectly printed. The correct image is mentioned below:

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Acknowledgments

This material is based on work supported in part by the US Department of Veterans Affairs, Office of Research and Development CSR&D Grant (CX000254-04). MI contribution was also funded by the Center for Language and Brain NRU Higher School of Economics, RF Government grant, ag. No. 14.641.31.0004. The contents reported/presented within do not represent the views of the Department of Veterans Affairs or the United States Government. We would like to thank our lab colleagues for their comments on earlier versions of the manuscript.

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Authors and Affiliations

  1. Center for Language, Imaging, Mind & Brain (CLIMB), VA Northern California Health Care System, Martinez, CA, USA

    Juliana V. Baldo, Maria V. Ivanova, Timothy J. Herron & Nina F. Dronkers

  2. Aphasia Recovery Lab, University of California, Berkeley, CA, USA

    Maria V. Ivanova & Nina F. Dronkers

  3. Center for Language and Brain, National Research University Higher School of Economics, Moscow, Russia

    Maria V. Ivanova

  4. Language Neuroscience Laboratory, Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, USA

    Stephen M. Wilson

  5. Department of Neurology, University of California, Davis, CA, USA

    Nina F. Dronkers

Authors
  1. Juliana V. Baldo
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  2. Maria V. Ivanova
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  3. Timothy J. Herron
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  4. Stephen M. Wilson
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  5. Nina F. Dronkers
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Corresponding author

Correspondence to Juliana V. Baldo .

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Editors and Affiliations

  1. Experimental Neuroimaging, CHDI Management/CHDI Foundation, Princeton, NJ, USA

    Dorian Pustina

  2. Department of Psychology, University of Edinburgh, Edinburgh, UK

    Daniel Mirman

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Baldo, J.V., Ivanova, M.V., Herron, T.J., Wilson, S.M., Dronkers, N.F. (2022). Voxel-Based Lesion Symptom Map**. In: Pustina, D., Mirman, D. (eds) Lesion-to-Symptom Map**. Neuromethods, vol 180. Springer, New York, NY. https://doi.org/10.1007/978-1-0716-2225-4_5

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  • DOI: https://doi.org/10.1007/978-1-0716-2225-4_5

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