Genomic technologies: development and clinical application

In this topical collection (16 articles)

1. Software

   Granatum: a graphical single-cell RNA-Seq analysis pipeline for genomics scientists

   Xun Zhu, Thomas K. Wolfgruber, Austin Tasato, Cédric Arisdakessian… Article:108

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2. Research

   Predicting cancer type from tumour DNA signatures

   Kee Pang Soh, Ewa Szczurek, Thomas Sakoparnig, Niko Beerenwinkel Article:104

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3. Research

   Next-generation map**: a novel approach for detection of pathogenic structural variants with a potential utility in clinical diagnosis

   Hayk Barseghyan, Wilson Tang, Richard T. Wang, Miguel Almalvez… Article:90

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4. Review

   Three-dimensional genome architecture and emerging technologies: loo** in disease

   Arpit Mishra, R. David Hawkins Article:87

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5. Method

   Differential analysis between somatic mutation and germline variation profiles reveals cancer-related genes

   Pawel F. Przytycki, Mona Singh Article:79

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6. Review

   A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications

   Ashraful Haque, Jessica Engel, Sarah A. Teichmann, Tapio Lönnberg Article:75

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7. Editorial

   Genomic technologies—from tools to therapies

   Andreia Cunha Article:71

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8. Method

   Interrogating the “unsequenceable” genomic trinucleotide repeat disorders by long-read sequencing

   Qian Liu, Peng Zhang, Depeng Wang, Weihong Gu, Kai Wang Article:65

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9. Research

   Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines

   Javier A. Alfaro, Alexandr Ignatchenko, Vladimir Ignatchenko… Article:62

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10. Review

    Advances in the delivery of RNA therapeutics: from concept to clinical reality

    James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson Article:60

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11. Software

    ISOWN: accurate somatic mutation identification in the absence of normal tissue controls

    Irina Kalatskaya, Quang M. Trinh, Melanie Spears, John D. McPherson… Article:59

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12. Opinion

    Computing patient data in the cloud: practical and legal considerations for genetics and genomics research in Europe and internationally

    Fruzsina Molnár-Gábor, Rupert Lueck, Sergei Yakneen, Jan O. Korbel Article:58

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13. Research

    Linked read sequencing resolves complex genomic rearrangements in gastric cancer metastases

    Stephanie U. Greer, Lincoln D. Nadauld, Billy T. Lau, Jiamin Chen… Article:57

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14. Comment

    Dissecting the human microbiome with single-cell genomics

    Andrew C. Tolonen, Ramnik J. Xavier Article:56

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15. Software

    brain-coX: investigating and visualising gene co-expression in seven human brain transcriptomic datasets

    Saskia Freytag, Rosemary Burgess, Karen L. Oliver, Melanie Bahlo Article:55

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16. Research

    Seed-effect modeling improves the consistency of genome-wide loss-of-function screens and identifies synthetic lethal vulnerabilities in cancer cells

    Alok Jaiswal, Gopal Peddinti, Yevhen Akimov, Krister Wennerberg… Article:51

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