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Structured Magnetic Core/Silica Internal Shell Layer and Protein Out Layer Shell (BSA@SiO2@SME): Preparation and Characterization

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Abstract

Purpose

Magnetic nanoparticles are an interesting approach in the biomedical and biotechnological field. They can be used as a drug delivery system or in magnetic resonance imaging. However, these particles have the disadvantage of being colloidally instable, easily oxidized, and suffer from partial toxicity. To overcome these problems, magnetic nanoparticles were coated by different types of coats such as silica, polymer, etc. the purpose of this study is to develop a coated iron oxide nanoparticle system.

Methods

Seed magnetic emulsion particles (SME) were first prepared and characterized before inducing silica layer using sol–gel process. The obtained SiO2@SME particles are then encapsulated using bovine serum albumin (BSA) layer. This proteins layer was performed via nanoprecipitation of BSA molecules on the SME. Particles were characterized by electron microscopy, FTIR, TGA, and zeta potential measurement.

Results

Characterization studies confirm the successful coating of BSA on the surface of amino-functionalized silica shell and magnetic core.

Conclusion

The used process leads to the preparation of highly magnetic particles encapsulated with silica layer ad then coated with proteins shell. The presence of silica shell will enhance the chemical stability of the magnetic core, whereas, the presence of proteins shell will improve low cytotoxicity and good biocompatibility in the contact with biological samples.

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Acknowledgements

Jaime Vega-Chacón would like to thank Coordenação de aperfeiçoamento de pessoal de nivel superior (CAPES) for the Grant funded Bolsista capes/Programa Doutorado Sanduíche no Exterior/Processo n° {88881.132878/2016-01}. Funding was provided by Campus France (Grant No. PHC PROCOPE 40544QH), Horizon 2020  research and innovation programme entitled (An integrated POC solution for non-invasive diagnosis and therapy monitoring of Heart Failure patients, KardiaTool) under grant agreement No 768686.

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Authors and Affiliations

  1. Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEP-UMR 5007, 69622, Lyon, France

    Mohamad Tarhini, Jaime Vega-Chacón, Hatem Fessi & Abdelhamid Elaissari

  2. Institute of Chemistry, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil

    Jaime Vega-Chacón & Miguel Jafelicci Jr.

  3. Institute of Analytical Sciences, UMR 5280, Claude Bernard Lyon 1 University, University of Lyon, Villeurbanne, France

    Nadia Zine & Abdelhamid Errachid

Authors
  1. Mohamad Tarhini
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  2. Jaime Vega-Chacón
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  3. Miguel Jafelicci Jr.
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  4. Nadia Zine
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  5. Abdelhamid Errachid
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  6. Hatem Fessi
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  7. Abdelhamid Elaissari
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Correspondence to Abdelhamid Elaissari.

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Tarhini, M., Vega-Chacón, J., Jafelicci, M. et al. Structured Magnetic Core/Silica Internal Shell Layer and Protein Out Layer Shell (BSA@SiO2@SME): Preparation and Characterization. Chemistry Africa 3, 127–134 (2020). https://doi.org/10.1007/s42250-019-00097-4

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  • DOI: https://doi.org/10.1007/s42250-019-00097-4

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