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La tiroidite di Hashimoto: proposta di aggiornamento dei criteri diagnostici

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L'Endocrinologo Aims and scope

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La tiroidite di Hashimoto (TH) è la malattia endocrina di più frequente osservazione, caratterizzata da una forte aggregazione familiare, dalla predilezione per il genere femminile e da un processo autoimmune con anticorpi antitiroide circolanti e, nella forma più completa, con un’infiltrazione linfocitaria della tiroide che causa ipotiroidismo e conferisce un tipico aspetto ipoecogeno della ghiandola all’ecografia. La diagnosi di TH viene spesso formulata in modo improprio in pazienti con anticorpi antitiroide ma senza un’infiltrazione linfocitaria diffusa della ghiandola e non destinati a sviluppare ipotiroidismo. In questa rassegna proponiamo che, accanto alla presenza di anticorpi antitiroide circolanti e allo stato funzionale di ipotiroidismo, l’aspetto ipoecogeno della ghiandola all’ecografia tiroidea sia incluso tra i criteri diagnostici “maggiori”, mentre l’aggregazione familiare e l’associazione con altre malattie autoimmuni costituiscano i criteri “minori”.

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Bibliografia

  1. Latrofa F, Pinchera A (2007) Autoimmune hypothyroidism. In: Weetman A (ed) Endocrinology. The Humana Press Inc, Totowa, pp 136–174

    Google Scholar 

  2. Rose NR, Witebsky E (1956) Studies on organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts. J Immunol 76(6):417–427

    CAS  PubMed  Google Scholar 

  3. Roitt IM, Doniach D, Campbell PN, Hudson RV (1956) Auto-antibodies in Hashimoto’s disease (lymphadenoid goitre). Lancet 271(6947):820–821

    Article  CAS  PubMed  Google Scholar 

  4. Rose NR, Twarog FJ, Crowle AJ (1971) Murine thyroiditis: importance of adjuvant and mouse strain for the induction of thyroid lesions. J Immunol 106(3):698–704

    CAS  PubMed  Google Scholar 

  5. McLachlan SM, Rapoport B (1992) The molecular biology of thyroid peroxidase: cloning, expression and role as autoantigen in autoimmune thyroid disease. Endocr Rev 13(2):192–206

    CAS  PubMed  Google Scholar 

  6. Vanderpump MP, Tunbridge WM, French JM et al. (1995) The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf) 43(1):55–68

    Article  CAS  Google Scholar 

  7. Hollowell JG, Staehling NW, Flanders WD et al. (2002) Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87(2):489–499

    Article  CAS  PubMed  Google Scholar 

  8. Mariotti S, Caturegli P, Piccolo P et al. (1990) Antithyroid peroxidase autoantibodies in thyroid diseases. J Clin Endocrinol Metab 71(3):661–669

    Article  CAS  PubMed  Google Scholar 

  9. Williams ED, Doniach I (1962) The post-mortem incidence of focal thyroiditis. J Pathol Bacteriol 83:255–264

    Article  CAS  PubMed  Google Scholar 

  10. Li Y, Nishihara E, Hirokawa M et al. (2010) Distinct clinical, serological, and sonographic characteristics of Hashimoto’s thyroiditis based with and without IgG4-positive plasma cells. J Clin Endocrinol Metab 95(3):1309–1317

    Article  CAS  PubMed  Google Scholar 

  11. Tomer Y, Davies TF (2003) Searching for the autoimmune thyroid disease susceptibility genes: from gene map** to gene function. Endocr Rev 24(5):694–717

    Article  CAS  PubMed  Google Scholar 

  12. Betterle C, Dal PC, Mantero F, Zanchetta R (2002) Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev 23(3):327–364

    Article  CAS  PubMed  Google Scholar 

  13. Ruggeri RM, Trimarchi F, Giuffrida G et al. (2017) Autoimmune comorbidities in Hashimoto’s thyroiditis: different patterns of association in adulthood and childhood/adolescence. Eur J Endocrinol 176(2):133–141

    Article  CAS  PubMed  Google Scholar 

  14. Caturegli P, De RA, Chuang K et al. (2013) Hashimoto’s thyroiditis: celebrating the centennial through the lens of the Johns Hopkins hospital surgical pathology records. Thyroid 23(2):142–150

    Article  PubMed  PubMed Central  Google Scholar 

  15. Strieder TG, Tijssen JG, Wenzel BE et al. (2008) Prediction of progression to overt hypothyroidism or hyperthyroidism in female relatives of patients with autoimmune thyroid disease using the Thyroid Events Amsterdam (THEA) score. Arch Intern Med 168(15):1657–1663

    Article  PubMed  Google Scholar 

  16. Marcocci C, Vitti P, Cetani F et al. (1991) Thyroid ultrasonography helps to identify patients with diffuse lymphocytic thyroiditis who are prone to develop hypothyroidism. J Clin Endocrinol Metab 72(1):209–213

    Article  CAS  PubMed  Google Scholar 

  17. Rago T, Chiovato L, Grasso L et al. (2001) Thyroid ultrasonography as a tool for detecting thyroid autoimmune diseases and predicting thyroid dysfunction in apparently healthy subjects. J Endocrinol Invest 24(10):763–769

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Pisa, Pisa, Italia

    Emilio Fiore, Teresa Rago & Paolo Vitti

  2. Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Messina, Messina, Italia

    Rosaria Maddalena Ruggeri

  3. Accademia Peloritana dei Pericolanti, Università degli Studi di Messina, Messina, Italia

    Francesco Trimarchi

Authors
  1. Emilio Fiore
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  2. Teresa Rago
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  3. Rosaria Maddalena Ruggeri
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  4. Francesco Trimarchi
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  5. Paolo Vitti
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Corresponding author

Correspondence to Emilio Fiore.

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Conflitto di interesse

Gli autori Emilio Fiore, Teresa Rago, Rosaria Maddalena Ruggeri, Francesco Trimarchi e Paolo Vitti dichiarano di non avere conflitti di interesse.

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Lo studio presentato in questo articolo non ha richiesto sperimentazione umana.

Studi sugli animali

Gli autori di questo articolo non hanno eseguito studi sugli animali.

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Proposto da Francesco Trimarchi.

Materiale elettronico supplementare

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Fiore, E., Rago, T., Ruggeri, R.M. et al. La tiroidite di Hashimoto: proposta di aggiornamento dei criteri diagnostici. L'Endocrinologo 19, 31–37 (2018). https://doi.org/10.1007/s40619-018-0398-3

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  • DOI: https://doi.org/10.1007/s40619-018-0398-3

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