Abstract
Background
Orthorexia nervosa (ON) has gained increasing interest in the last 2 decades. Although a consensus on the diagnostic boundaries of ON has not yet been reached, there is some evidence for an overlap with eating disorders, obsessive–compulsive disorder, and psychotic disorder. Most of the knowledge about ON has emerged from studies of non-clinical and at-risk populations and is focused on differential diagnosis; therefore, further clinical studies are needed to better outline the ON phenomenon in a real-life setting.
Objective
This case series aims at describing clinical cases that developed symptoms suggestive of ON after being diagnosed with a prior psychiatric disorder and then discussing them in light of possible clinical pathways.
Methods
Four women consecutively admitted to an outpatient unit for the treatment of eating disorders were diagnosed with ON through a clinical interview, according to Dunn and Bratman’s criteria and self-administered questionnaire assessment (ORTO-15), and were considered to be eligible for this case series study. Psychiatric anamnestic data were collected retrospectively.
Results
The anamnesis revealed that all patients were previously diagnosed with a psychiatric disorder (i.e. obsessive–compulsive disorder, bulimia nervosa, illness anxiety disorder, and psychotic disorder) before develo** ON.
Conclusion
Past literature focused on differential diagnosis between ON and other psychiatric disorders. This is the first description of clinical cases in a real-life setting that started with different psychiatric disorders and later developed symptoms suggestive of ON. These cases have generated a new research question on the possibility that different psychiatric disorders may associate with a later onset of ON.
Level of evidence
Level V, descriptive study.
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References
Bratman S (1997) Health food junkie. Yoga J 136:42–50
Cena H, Barthels F, Cuzzolaro M et al (2018) Definition and diagnostic criteria for orthorexia nervosa: a narrative review of the literature. Eat Weight Disord Stud Anorex Bulim Obes. https://doi.org/10.1007/s40519-018-0606-y
Setnick J (2013) The eating disorders clinical pocket guide, second edition: quick reference for healthcare providers. Understanding Nutrition, Dallas
Moroze RM, Dunn TM, Craig Holland J et al (2015) Microthinking about micronutrients: a case of transition from obsessions about healthy eating to near-fatal “orthorexia nervosa” and proposed diagnostic criteria. Psychosomatics 56:397–403. https://doi.org/10.1016/j.psym.2014.03.003
Barthels F (2014) Orthorektisches Ernährungsverhalten—Psychologische Untersuchungen zu einem neuen Störungsbild. Heinrich-Heine-Universität Düsseldorf, Institut für Experimentelle Psychologie. Promotion in Psychologie.
Dunn TM, Bratman S (2016) On orthorexia nervosa: A review of the literature and proposed diagnostic criteria. Eat Behav 21:11–17. https://doi.org/10.1016/j.eatbeh.2015.12.006
Koven NS, Wabry A (2015) The clinical basis of orthorexia nervosa: emerging perspectives. Neuropsychiatr Dis Treat 11:385–394. https://doi.org/10.2147/NDT.S61665
Lopes R, Melo R, Dias Pereira B (2020) Orthorexia nervosa and comorbid depression successfully treated with mirtazapine: a case report. Eat Weight Disord 25:163–167. https://doi.org/10.1007/s40519-018-0539-5
Hunter JD, Crudo DF (2018) Unintended consequences of restrictive diets: two case reports and a review of orthorexia. Clin Pediatr (Phila) 57:1693–1695. https://doi.org/10.1177/0009922818795905
Park SW, Kim JY, Go GJ et al (2011) Orthorexia nervosa with hyponatremia, subcutaneous emphysema, pneumomediastimum, pneumothorax, and pancytopenia. Electrolytes Blood Press 9:32. https://doi.org/10.5049/EBP.2011.9.1.32
Catalina Zamora ML, Bote Bonaechea B, García Sánchez F, Ríos Rial B (2005) Orthorexia nervosa. A new eating behavior disorder? Actas Esp Psiquiatr 33:66–8
Saddichha S, Babu GN, Chandra P (2012) Orthorexia nervosa presenting as prodrome of schizophrenia. Schizophr Res 134:110. https://doi.org/10.1016/j.schres.2011.10.017
Segura-Garcia C, Ramacciotti C, Rania M et al (2015) The prevalence of orthorexia nervosa among eating disorder patients after treatment. Eat Weight Disord. https://doi.org/10.1007/s40519-014-0171-y
First MB (2016) SCID-5-CV : structured clinical interview for DSM-5 disorders, clinician version. American Psychiatric Association
Calugi S, Milanese C, Sartirana M et al (2017) The Eating Disorder Examination Questionnaire: reliability and validity of the Italian version. Eat Weight Disord 22:509–514. https://doi.org/10.1007/s40519-016-0276-6
Donini LM, Marsili D, Graziani MP et al (2005) Orthorexia nervosa: validation of a diagnosis questionnaire. Eat Weight Disord 10:e28–e32. https://doi.org/10.1007/BF03327537
Segura-García C, Papaianni MC, Caglioti F et al (2012) Orthorexia nervosa: A frequent eating disordered behavior in athletes. Eat Weight Disord. https://doi.org/10.3275/8272
Mathieu J (2005) What Is orthorexia? J Am Diet Assoc 105:1510–1512. https://doi.org/10.1016/j.jada.2005.08.021
Musolino C, Warin M, Wade T, Gilchrist P (2015) ‘Healthy anorexia’: the complexity of care in disordered eating. Soc Sci Med 139:18–25. https://doi.org/10.1016/j.socscimed.2015.06.030
Hadjistavropoulos H, Lawrence B (2007) Does anxiety about health influence eating patterns and shape-related body checking among females? Perspect Individ Differ 43:319–328. https://doi.org/10.1016/j.paid.2006.11.021
Kiss-Leizer M, Rigó A (2018) People behind unhealthy obsession to healthy food: the personality profile of tendency to orthorexia nervosa. Eat Weight Disord. https://doi.org/10.1007/s40519-018-0527-9
Aarnio K, Lindeman M (2004) Magical food and health beliefs: a portrait of believers and functions of the beliefs. Appetite 43:65–74. https://doi.org/10.1016/j.appet.2004.03.002
Lindeman M, Keskivaara P, Roschier M (2000) Assessment of magical beliefs about food and health. J Health Psychol 5:195–209. https://doi.org/10.1177/135910530000500210
Pincus HA, Tew JD, First MB, First MB (2004) Psychiatric comorbidity: Is more less? World Psychiatry 3:18–23
McComb SE, Mills JS (2019) Orthorexia nervosa: a review of psychosocial risk factors. Appetite 140:50–75. https://doi.org/10.1016/j.appet.2019.05.005
Gordon OM, Salkovskis PM, Oldfield VB, Carter N (2013) The association between obsessive compulsive disorder and obsessive compulsive personality disorder: prevalence and clinical presentation. Br J Clin Psychol 52:300–315. https://doi.org/10.1111/bjc.12016
Starcevic V, Berle D, Brakoulias V et al (2013) Obsessive-compulsive personality disorder co-occurring with obsessive-compulsive disorder: Conceptual and clinical implications. Aust N Z J Psychiatry 47:65–73. https://doi.org/10.1177/0004867412450645
Halmi KA, Tozzi F, Thornton LM et al (2005) The relation among perfectionism, obsessive-compulsive personality disorder and obsessive-compulsive disorder in individuals with eating disorders. Int J Eat Disord 38:371–374. https://doi.org/10.1002/eat.20190
Altman SE, Shankman SA (2009) What is the association between obsessive–compulsive disorder and eating disorders? Clin Psychol Rev 29:638–646. https://doi.org/10.1016/j.cpr.2009.08.001
Serpell L, Livingstone A, Neiderman M, Lask B (2002) Anorexia nervosa: obsessive-compulsive disorder, obsessive-compulsive personality disorder, or neither? Clin Psychol Rev 22:647–669
Aloi M, Rania M, Caroleo M et al (2015) Decision making, central coherence and set-shifting: a comparison between binge eating disorder, anorexia nervosa and healthy controls. BMC Psychiatry. https://doi.org/10.1186/s12888-015-0395-z
Martinez G, Cook-Darzens S, Chaste P et al (2014) L’anorexie mentale à la lumière du fonctionnement neurocognitif: nouvelles perspectives théoriques et thérapeutiques. Encephale 40:160–167. https://doi.org/10.1016/j.encep.2012.06.004
Chamberlain SR, Blackwell AD, Fineberg NA et al (2005) The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Rev 29:399–419. https://doi.org/10.1016/j.neubiorev.2004.11.006
Koven NS, Senbonmatsu R, Koven NS, Senbonmatsu R (2013) A neuropsychological evaluation of orthorexia nervosa. Open J Psychiatry 03:214–222. https://doi.org/10.4236/ojpsych.2013.32019
Zucker N, Wagner HR, Merwin R et al (2015) Self-focused attention in anorexia nervosa. Int J Eat Disord 48:9–14. https://doi.org/10.1002/eat.22307
O’Kearney R, Nicholson C (2008) Can a theory of mind disruption help explain OCD related metacognitive disturbances? Behav Change 25:55–70. https://doi.org/10.1375/bech.25.2.55
Kiss-Leizer M, Tóth-Király I, Rigó A (2019) How the obsession to eat healthy food meets with the willingness to do sports: the motivational background of orthorexia nervosa. Eat Weight Disord 24:465–472. https://doi.org/10.1007/s40519-019-00642-7
Arhire LI (2015) Orthorexia Nervosa: the unhealthy obssesion for healthy food. Med Surg J 119:632–638
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Authors are grateful to patients who agreed to collaborate with researchers to this study.
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Rania, M., de Filippis, R., Caroleo, M. et al. Pathways to orthorexia nervosa: a case series discussion. Eat Weight Disord 26, 1675–1683 (2021). https://doi.org/10.1007/s40519-020-00948-x
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DOI: https://doi.org/10.1007/s40519-020-00948-x