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Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

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Abstract

Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcuma longa. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.

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Acknowledgments

The support provided by the Iran National Science Foundation (Tehran, Iran) is gratefully acknowledged.

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Authors and Affiliations

  1. Student Research Committee, Department of Medical Biotechnology, Nanotechnology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Amir Abbas Momtazi

  2. Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy

    Giuseppe Derosa

  3. Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy

    Giuseppe Derosa & Pamela Maffioli

  4. Department of Hypertension, Medical University of Lodz, Lodz, Poland

    Maciej Banach

  5. Healthy Aging Research Centre (HARC), Medical University of Lodz, Lodz, Poland

    Maciej Banach

  6. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  7. Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia

    Amirhossein Sahebkar

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  1. Amir Abbas Momtazi
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  2. Giuseppe Derosa
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  3. Pamela Maffioli
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  4. Maciej Banach
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  5. Amirhossein Sahebkar
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Correspondence to Amirhossein Sahebkar.

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Amir Abbas Momtazi, Giuseppe Derosa, Pamela Maffioli, Maciej Banach, and Amirhossein Sahebkar declare that they have no conflicts of interest.

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No funding was received for this study.

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Momtazi, A.A., Derosa, G., Maffioli, P. et al. Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases. Mol Diagn Ther 20, 335–345 (2016). https://doi.org/10.1007/s40291-016-0202-7

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