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Role of ferritin and oxidative stress index in gestational diabetes mellitus

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Abstract

Objectives

To investigate the role of serum ferritin and oxidative stress in the development of GDM and to assess their relationship with the ensuing hyperglycemia.

Methods

A case–control study was carried on 90 non-anemic pregnant women of 20–40 years with a gestation of 24–28 weeks. Study group (n = 65) was identified according to the Diabetes in Pregnancy Study Group India (DIPSI) criteria (2-h plasma glucose ≥ 140 mg/dl) and controls (n = 25) having 2-h plasma glucose < 120 mg/dl. DIPSI 2-h plasma glucose, HbA1c and serum ferritin were measured and oxidative stress index (OSI) was calculated. Statistical tests were performed using SPSS version 25.0.

Results

Pre-pregnancy BMI showed a significant difference between control and study group. DIPSI 2 h blood glucose, HbA1c, serum ferritin and OSI were significantly higher in study group compared to control group. Both 2 h blood glucose and HbA1c were positively correlated with serum ferritin and OSI, serum ferritin and OSI were also positively correlated with each other.

Conclusion

Higher pre-pregnancy BMI elevates serum ferritin, which in turn increases the OSI. Both ferritin and oxidative stress raises 2 h blood glucose and HbA1c in GDM patients possibly by causing in-vivo pancreatic β –cell injury and death (ferroptosis). Serum ferritin and OSI could become newer personalized theranostic and monitoring targets in overweight/obese pregnant females especially GDM patients.

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Authors and Affiliations

  1. Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, 202002, UP, India

    Surabhi Gautam, Feroz Alam & S. H. Arif

  2. Department of Biochemistry, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, 202002, UP, India

    Shagufta Moin

  3. Department of Obstetrics & Gynaecology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, 202002, UP, India

    Nasreen Noor

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  1. Surabhi Gautam
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Correspondence to Feroz Alam.

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Gautam, S., Alam, F., Moin, S. et al. Role of ferritin and oxidative stress index in gestational diabetes mellitus. J Diabetes Metab Disord 20, 1615–1619 (2021). https://doi.org/10.1007/s40200-021-00911-2

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