Log in

Is There a Role for MRI in the Management of Placenta Accreta Spectrum?

  • Aberrant Placentation: Contemporary Management of Placenta Accreta (E Jauniaux, Section Editor)
  • Published:
Current Obstetrics and Gynecology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The diagnosis of placenta accreta spectrum (PAS) is based on evaluation of risk factors and imaging findings. Ultrasound (US) is widely available and relatively cheap; magnetic resonance imaging (MRI) is expensive and not universally available. We review performance, interpretation, accuracy, and pitfalls of MRI, and whether it has a role in the management of PAS.

Recent Findings

Recent meta-analyses showed excellent diagnostic accuracy in depth of placental invasion. Specific MRI features (intraplacental T2 dark bands, myometrial disruption, uterine bulge, and uteroplacental or parametrial hypervascularity) were shown to have significant association with clinical outcomes. The presence of at least three MRI signs was associated with complicated delivery; the presence of six or more MRI signs was associated with massive bleeding, hysterectomy, or extensive bladder repair.

Summary

MRI is performed on patients with high suspicion for PAS based on risk factors and abnormal US findings. Thus, the pretest probability is very high, artificially inflating sensitivity and specificity. The FIGO consensus recommendation states that MRI is not essential for diagnosis of PAS. When selectively performed, and interpreted by experts, it may be useful in evaluation of areas difficult to see on US and in determining the full extent of placenta percreta. Imaging findings should be reviewed together with clinical information, an attempt made to reconcile any differences in interpretation, and if findings remain discordant, management should err on the side of the most severe assessment of this highly morbid condition which can lead to maternal mortality if unrecognized.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Brazil)

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Kay HH, Spritzer CE. Preliminary experience with magnetic resonance imaging in patients with third-trimester bleeding. Obstet Gynecol. 1991;78(3 Pt 1):424–9.

    CAS  PubMed  Google Scholar 

  2. Levine D, Hulka CA, Ludmir J, Li W, Edelman RR. Placenta accreta: evaluation with color Doppler US, power Doppler US, and MR imaging. Radiology. 1997;205(3):773–6.

    Article  CAS  PubMed  Google Scholar 

  3. American College of Radiology. ACR SPR practice parameter for the safe and optimal performance of fetal magnetic resonance imaging (MRI). https://www.acr.org/-/media/ACR/Files/Practice-Parameters/mr-fetal.pdf Accessed April 27, 2019.

  4. Horowitz JM, Berggruen S, McCarthy RJ, Chen MJ, Hammond C, Trinh A, et al. When timing is everything: are placental MRI examinations performed before 24 Weeks' gestational age reliable? AJR Am J Roentgenol. 2015;205(3):685–92.

    Article  PubMed  Google Scholar 

  5. Kilcoyne A, Shenoy-Bhangle AS, Roberts DJ, Sisodia RC, Gervais DA, Lee SI. MRI of placenta Accreta, placenta increta, and placenta Percreta: pearls and pitfalls. AJR Am J Roentgenol. 2017;208(1):214–21.

    Article  PubMed  Google Scholar 

  6. Goergen SK, Posma E, Wrede D, Collett J, Pyman J, Alibrahim E, et al. Interobserver agreement and diagnostic performance of individual MRI criteria for diagnosis of placental adhesion disorders. Clin Radiol. 2018;73(10):908 e1–9.

    Article  Google Scholar 

  7. Morita S, Ueno E, Fujimura M, Muraoka M, Takagi K, Fujibayashi M. Feasibility of diffusion-weighted MRI for defining placental invasion. J Magn Reson Imaging. 2009;30(3):666–71.

    Article  PubMed  Google Scholar 

  8. Millischer AE, Deloison B, Silvera S, Ville Y, Boddaert N, Balvay D, et al. Dynamic contrast enhanced MRI of the placenta: a tool for prenatal diagnosis of placenta accreta? Placenta. 2017;53:40–7.

    Article  CAS  PubMed  Google Scholar 

  9. Millischer AE, Salomon LJ, Porcher R, Brasseur-Daudruy M, Gourdier AL, Hornoy P, et al. Magnetic resonance imaging for abnormally invasive placenta: the added value of intravenous gadolinium injection. BJOG. 2017;124(1):88–95.

    Article  CAS  PubMed  Google Scholar 

  10. Oh KY, Roberts VH, Schabel MC, Grove KL, Woods M, Frias AE. Gadolinium chelate contrast material in pregnancy: fetal biodistribution in the nonhuman primate. Radiology. 2015;276(1):110–8.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Webb JA, Thomsen HS. Gadolinium contrast media during pregnancy and lactation. Acta Radiol. 2013;54(6):599–600.

    Article  PubMed  Google Scholar 

  12. Tremblay E, Therasse E, Thomassin-Naggara I, Trop I. Quality initiatives: guidelines for use of medical imaging during pregnancy and lactation. Radiographics. 2012;32(3):897–911.

    Article  PubMed  Google Scholar 

  13. Do QN, Lewis MA, Madhuranthakam AJ, ** Y, Bailey AA, Lenkinski RE, et al. Texture analysis of magnetic resonance images of the human placenta throughout gestation: a feasibility study. PLoS One. 2019;14(1):e0211060.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Baughman WC, Corteville JE, Shah RR. Placenta accreta: spectrum of US and MR imaging findings. Radiographics. 2008;28(7):1905–16.

    Article  PubMed  Google Scholar 

  15. Balcacer P, Pahade J, Spektor M, Staib L, Copel JA, McCarthy S. Magnetic resonance imaging and sonography in the Diagnosis of placental invasion. J Ultrasound Med. 2016;35(7):1445–56.

    Article  PubMed  Google Scholar 

  16. Bourgioti C, Zafeiropoulou K, Fotopoulos S, Nikolaidou ME, Antoniou A, Tzavara C, et al. MRI features predictive of invasive placenta with Extrauterine spread in high-risk gravid patients: a prospective evaluation. AJR Am J Roentgenol. 2018;211(3):701–11.

    Article  PubMed  Google Scholar 

  17. • Bourgioti C, Zafeiropoulou K, Fotopoulos S, Nikolaidou ME, Theodora M, Daskalakis G, et al. MRI prognosticators for adverse maternal and neonatal clinical outcome in patients at high risk for placenta accreta spectrum (PAS) disorders. J Magn Reson Imaging. 2018; This study correlated specific MRI features with clinical outcomes and found the presence of ≥ 3 MRI signs correlated with a complicated delivery and ≥ 6 with massive bleeding, hysterectomy or extensive bladder repair.

  18. Chen X, Shan R, Zhao L, Song Q, Zuo C, Zhang X, et al. Invasive placenta previa: placental bulge with distorted uterine outline and uterine serosal hypervascularity at 1.5T MRI - useful features for differentiating placenta percreta from placenta accreta. Eur Radiol. 2018;28(2):708–17.

    Article  PubMed  Google Scholar 

  19. D'Antonio F, Iacovella C, Palacios-Jaraquemada J, Bruno CH, Manzoli L, Bhide A. Prenatal identification of invasive placentation using magnetic resonance imaging: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2014;44(1):8–16.

    Article  CAS  PubMed  Google Scholar 

  20. Derman AY, Nikac V, Haberman S, Zelenko N, Opsha O, Flyer M. MRI of placenta accreta: a new imaging perspective. AJR Am J Roentgenol. 2011;197(6):1514–21.

    Article  PubMed  Google Scholar 

  21. • Familiari A, Liberati M, Lim P, Pagani G, Cali G, Buca D, et al. Diagnostic accuracy of magnetic resonance imaging in detecting the severity of abnormal invasive placenta: a systematic review and meta-analysis. Acta Obstet Gynecol Scand. 2018;97(5):507–20 This is the largest, most recent meta-analysis showing very high sensitivity and specificity of MRI for PAS but acknowledging a high pretest probabilty.

    Article  PubMed  Google Scholar 

  22. Lax A, Prince MR, Mennitt KW, Schwebach JR, Budorick NE. The value of specific MRI features in the evaluation of suspected placental invasion. Magn Reson Imaging. 2007;25(1):87–93.

    Article  PubMed  Google Scholar 

  23. Maurea S, Romeo V, Mainenti PP, Ginocchio MI, Frauenfelder G, Verde F, et al. Diagnostic accuracy of magnetic resonance imaging in assessing placental adhesion disorder in patients with placenta previa: correlation with histological findings. Eur J Radiol. 2018;106:77–84.

    Article  CAS  PubMed  Google Scholar 

  24. Meng X, **e L, Song W. Comparing the diagnostic value of ultrasound and magnetic resonance imaging for placenta accreta: a systematic review and meta-analysis. Ultrasound Med Biol. 2013;39(11):1958–65.

    Article  PubMed  Google Scholar 

  25. Jauniaux E, Chantraine F, Silver RM, Langhoff-Roos J, Diagnosis FPA, Management Expert Consensus P. FIGO consensus guidelines on placenta accreta spectrum disorders: epidemiology. Int J Gynaecol Obstet. 2018;140(3):265–73.

    Article  PubMed  Google Scholar 

  26. Ueno Y, Kitajima K, Kawakami F, Maeda T, Suenaga Y, Takahashi S, et al. Novel MRI finding for diagnosis of invasive placenta praevia: evaluation of findings for 65 patients using clinical and histopathological correlations. Eur Radiol. 2014;24(4):881–8.

    Article  PubMed  Google Scholar 

  27. Palacios Jaraquemada JM, Bruno CH. Magnetic resonance imaging in 300 cases of placenta accreta: surgical correlation of new findings. Acta Obstet Gynecol Scand. 2005;84(8):716–24.

    Article  PubMed  Google Scholar 

  28. Dighe M. MR imaging of abnormal placentation. Magn Reson Imaging Clin N Am. 2017;25(3):601–10.

    Article  PubMed  Google Scholar 

  29. Fukuda M, Fukuda K, Shimizu T, Bujold E. Ultrasound assessment of lower uterine segment thickness during pregnancy, labour, and the postpartum period. J Obstet Gynaecol Can. 2016;38(2):134–40.

    Article  PubMed  Google Scholar 

  30. Tantbirojn P, Crum CP, Parast MM. Pathophysiology of placenta creta: the role of decidua and extravillous trophoblast. Placenta. 2008;29(7):639–45.

    Article  CAS  PubMed  Google Scholar 

  31. Dwyer BK, Belogolovkin V, Tran L, Rao A, Carroll I, Barth R, et al. Prenatal diagnosis of placenta accreta: sonography or magnetic resonance imaging? J Ultrasound Med. 2008;27(9):1275–81.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Einerson BD, Rodriguez CE, Kennedy AM, Woodward PJ, Donnelly MA, Silver RM. Magnetic resonance imaging is often misleading when used as an adjunct to ultrasound in the management of placenta accreta spectrum disorders. Am J Obstet Gynecol. 2018;218(6):618 e1–7.

    Article  Google Scholar 

  33. Silver RM, Fox KA, Barton JR, Abuhamad AZ, Simhan H, Huls CK, et al. Center of excellence for placenta accreta. Am J Obstet Gynecol. 2015;212(5):561–8.

    Article  PubMed  Google Scholar 

  34. •• Jauniaux E, Bhide A, Kennedy A, Woodward P, Hubinont C, Collins S, et al. FIGO consensus guidelines on placenta accreta spectrum disorders: Prenatal diagnosis and screening. Int J Gynaecol Obstet. 2018;140(3):274–80 The FIGO consensus recommendation states that MRI is not essential for making a prenatal diagnosis of suspected PAS disorders but may be useful in evaluating the pelvic extension of a placenta percreta or areas difficult to evaluate on US.

    Article  PubMed  Google Scholar 

  35. Palacios-Jaraquemada JM, Bruno CH, Martin E. MRI in the diagnosis and surgical management of abnormal placentation. Acta Obstet Gynecol Scand. 2013;92(4):392–7.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paula J. Woodward.

Ethics declarations

Conflict of Interest

Paula J. Woodward, Anne Kennedy, and Brett D. Einerson declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Aberrant Placentation: Contemporary Management of Placenta Accreta

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Woodward, P.J., Kennedy, A. & Einerson, B.D. Is There a Role for MRI in the Management of Placenta Accreta Spectrum?. Curr Obstet Gynecol Rep 8, 64–70 (2019). https://doi.org/10.1007/s13669-019-00266-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13669-019-00266-9

Keywords

Navigation