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MiR-186 targets ROCK1 to suppress the growth and metastasis of NSCLC cells

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Tumor Biology

Abstract

MicroRNAs (miRNAs) act as oncogenes or tumor suppressors in human cancers. Increasing evidence shows that deregulation of miRNAs contributes to the development and progression of human non-small cell lung cancer (NSCLC). Here, we identified miR-186 as a tumor suppressor in NSCLC, which was decreased in NSCLC. Overexpression of miR-186 significantly inhibited proliferation, migration, and invasion of NSCLC cells. In addition, Rho-associated protein kinase 1 (ROCK1) was identified as a target of miR-186 in NSCLC cells. Restoration of ROCK1 remarkably reversed the tumor-suppressive effects of miR-186 on cell proliferation, migration, and invasion in NSCLC cells. Furthermore, ROCK1 was inversely correlated with miR-186 expression in NSCLC. Collectively, our data indicate that miR-186 functions as tumor suppressor in NSCLC by targeting ROCK1.

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Authors and Affiliations

  1. Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, 450000, Zhengzhou, China

    Guanghui Cui, Yuhang Li, Youguang Liang, Weihao Li, Haizhou Guo & Song Zhao

  2. School of Basic Medical Science, Peking University Health Science Center, 100191, Bei**g, China

    Mingwei Cui

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  1. Guanghui Cui
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  2. Mingwei Cui
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  3. Yuhang Li
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  4. Youguang Liang
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  5. Weihao Li
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  6. Haizhou Guo
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  7. Song Zhao
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Corresponding author

Correspondence to Song Zhao.

Additional information

Guanghui Cui and Mingwei Cui equally contributed to this work.

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Cui, G., Cui, M., Li, Y. et al. MiR-186 targets ROCK1 to suppress the growth and metastasis of NSCLC cells. Tumor Biol. 35, 8933–8937 (2014). https://doi.org/10.1007/s13277-014-2168-6

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  • DOI: https://doi.org/10.1007/s13277-014-2168-6

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