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Functional Polyelectrolyte Coatings on Polymeric and Magnetic Colloidal Particles for Antifouling and Non-Toxic Bioconjugate Nanoparticles

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Abstract

In this paper, we used H-bonding and/or electrostatic force-driven polyelectrolyte multilayer (PEM) coatings on the surface of magnetic (paramagnetic and ferromagnetic) colloidal particles to prevent irreversible coagulation and introduce biochemical moieties. Polyacrylamide (PAAm), poly(acrylic acid) (PAA), and a cationic modified cyclodextrin polymer P(β-CyD) were used for the coating. Through the chemical groups of the PEM coating the RGD-peptide ligand was introduced on the magnetic particles, which enhanced strong specific cell-magnetic particle interactions. P(β-CyD)-containing surface-coated magnetic particles also show great potential in cell culture. These functional PEM coatings on magnetic colloidal particles may have great potential in bio-applications including targeted intracellular drug delivery.

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Acknowledgment

This work was supported by the Chungnam National University fund and the National Research Foundation (NRF-2020R1A2-C2009666).

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Authors and Affiliations

  1. Departments of Polymer Science and Engineering, Graduate School of Chungnam National University, 99 Daehak-Ro, Yuseong-Gu, Daejeon, 34134, Korea

    Nguyen Thi Thuy Chau, Eun-Seo Koh, Su-** Lee, Zhou Rui & Sung Yun Yang

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  1. Nguyen Thi Thuy Chau
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  2. Eun-Seo Koh
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  3. Su-** Lee
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  4. Zhou Rui
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  5. Sung Yun Yang
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Correspondence to Sung Yun Yang.

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Experimental procedure for the synthesis of PEM films on magnetic particles is provided. The materials are available via the Internet at http://www.springer.com/13233.

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Chau, N.T.T., Koh, ES., Lee, SJ. et al. Functional Polyelectrolyte Coatings on Polymeric and Magnetic Colloidal Particles for Antifouling and Non-Toxic Bioconjugate Nanoparticles. Macromol. Res. 29, 843–846 (2021). https://doi.org/10.1007/s13233-021-9102-8

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  • DOI: https://doi.org/10.1007/s13233-021-9102-8

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