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Antimycobacterial potentials of quercetin and rutin against Mycobacterium tuberculosis H37Rv

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Abstract

Quercetin and rutin, two flavonoids were examined for antimycobacterial activities against M. tuberculosis H37Rv (ATCC 27294). The quercetin exhibited (99.30 ± 0.268%) in (LRP) assay at 200 µg/ml and 56.21 ± 0.97% inhibition in (BMD) at 50 µg/ml, whereas rutin exhibited (90.40 ± 0.68%) in LRP assay at 200 µg/ml and 56.10 ± 0.67% inhibition in BMD at 50 µg/ml. The minimum inhibitory concentration (MIC) was found to be 6.25 µg ml−1 and 25 µg ml−1 respectively. The current investigation suggests that quercetin has better inhibitory activity than rutin.

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Acknowledgements

We are grateful to Dr. Uma Devi, HOD, Department of Bacteriology, National Institute for Research in Tuberculosis (ICMR), Chennai, India for performing antituberculosis assays. Authors are also thankful to the management of VIT University for their support.

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Authors and Affiliations

  1. Department of Integrative Biology, School of BioSciences and Technology (SBST), VIT University, Vellore, Tamilnadu, 632014, India

    Kandasamy Sasikumar & Asit Ranjan Ghosh

  2. Department of Bacteriology, National Institute for Research in Tuberculosis (NIRT-ICMR), Chennai, Tamilnadu, 600031, India

    Azger Dusthackeer

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  1. Kandasamy Sasikumar
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  2. Asit Ranjan Ghosh
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  3. Azger Dusthackeer
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Correspondence to Asit Ranjan Ghosh.

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Sasikumar, K., Ghosh, A.R. & Dusthackeer, A. Antimycobacterial potentials of quercetin and rutin against Mycobacterium tuberculosis H37Rv. 3 Biotech 8, 427 (2018). https://doi.org/10.1007/s13205-018-1450-5

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