Abstract
Objectives
Study includes 20 patients with diagnosis of fascial space infections of odontogenic origin to assess efficacy of serum prealbumin and CRP levels as monitoring tools for determining severity of infections, nutritional status, hospital stay and efficacy of treatment.
Methods
Blood samples taken on day 0, 4, and 8 for measuring serum levels of markers. Simultaneously clinical parameters like swelling size, pain etc., were also recorded on day 0, 4, and 8 and appropriate treatment given to each patient. Correlation between markers and parameters was found using regression and paired t test.
Results
Statistical analysis found strong correlation between laboratory values of markers and parameters used to measure severity of infection also. Prealbumin and crp are significant markers for hospital stay (p < 0.01). Prealbumin also found to be a sensitive indicator of nutritional status (p < 0.001).
Interpretation and Conclusion
Prospective analysis indicates prealbumin and crp are effective markers for determining severity of infection, treatment efficacy and hospital stay. Prealbumin is also sensitive marker for nutritional status. Duration of antibiotic usage, intensive unit care, use of nutritional supplements becomes more rationale. Markers also make treatment cost effective and help protecting patients from side effects of excess drug usage.
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References
Ylyjoki S, Suuronen R, Somer HJ, Meurman JH, Lindqvist C (2001) Differences between patients with or without the need for intensive care due to severe odontogenic infections. J Oral Maxillofac Surg 59:867–872
Ren YF et al (2007) Rapid quantitative determination of C-reactive protein at chair side in dental emergency patients. J Tripleo 104(1):49–55
Sganga et al (1985) Hepatic protein repriosation after trauma and sepsis. J Surg 120:189–199
Cunningham LL, Madsen JM, Sickels VEJ (2006) Using prealbumin as antinflammatory marker for patients with deep space infections of odontogenic origin. J Oral Maxillofac 64:375–378
Sann L et al (1984) Evolution of serum prealbumin, C-reactive protein, and orosomucoid in neonates with bacterial infection. J Pediatr 105(977–981):4
Sabel KG, Wadsworth C (1979) C-reactive protein in early diagnosis of neonatal septicemia. Acta Paediatr Scand 68:825–831
Stahl WM (1987) Acute phase protein response to tissue injury. Crit Care Med 15(6):545–550
Malve I (1998) Serum levels of thyroxine binding prealbumin, C-reactive protein and IL-6 in protein–energy undernourished children and normal controls without or with associated clinical infections. J Trop Pediatr 44:256–262
Pinilla JC et al (1998) The C-reactive protein to prealbumin ratio correlates with the severity of multiple organ dysfunctions. Surgery 124:799–806
Ingenbleek Y, De Visscher M, De Nayer P (1972) Measurement of prealbumin as an index of protein calorie malnutrition. Lancet (July):106–108
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Sharma, A., Giraddi, G., Krishnan, G. et al. Efficacy of Serum Prealbumin and CRP Levels as Monitoring Tools for Patients with Fascial Space Infections of Odontogenic Origin: A Clinicobiochemical Study. J. Maxillofac. Oral Surg. 13, 1–9 (2014). https://doi.org/10.1007/s12663-012-0376-4
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DOI: https://doi.org/10.1007/s12663-012-0376-4