Abstract
The patient was a 57-year-old man who had undergone endoscopic submucosal dissection for early esophageal cancer (distance from incisor tooth, 30 cm) when he was 50 years of age. Pathological findings showed squamous cell carcinoma invading the lamina muscularis mucosae and mild lymphatic invasion. Considering the possibility of lymph node metastasis and distant metastasis, we administered radiation chemotherapy (CDDP+ 5-FU, total radiation 41.4 Gy) in the same year. Two years later, follow-up endoscopy revealed a white, flat, elevated lesion in the thoracic esophagus (distance from incisor tooth, 36 cm) that was not stained by Lugol’s iodine. A biopsy of this lesion was performed. Although esophageal epidermization was seen, there were no findings suggestive of malignancy. The lesion grew slightly during four and a half years of follow-up after identification. We performed a repeat biopsy of the lesion, and the tissue was diagnosed as atypical epithelium, so we performed endoscopic mucosal resection for diagnostic and therapeutic purposes. The postoperative pathological diagnosis was squamous cell carcinoma of T1a-LPM with epidermization due to its histological features. To the best of our knowledge, this is the first report of esophageal cancer accompanied by epidermization.
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Satoshi Yamanouchi, Yukiko Sako, Shinsuke Suemitsu, Kousuke Tsukano, Satoshi Kotani, Ryusaku Kusunoki, Youichi Miyaoka, Tatsuya Miyake, Hirofumi Fujishiro, Naruaki Kohge, Tomohiko Yamamoto and Hideyuki Oonuma declare that they have no conflict interest.
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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).
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Informed consent was obtained from this patient for being included in this case report.
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Yamanouchi, S., Sako, Y., Suemitsu, S. et al. Early esophageal cancer with epidermization diagnosed and treated with endoscopic resection. Clin J Gastroenterol 11, 29–33 (2018). https://doi.org/10.1007/s12328-017-0792-6
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DOI: https://doi.org/10.1007/s12328-017-0792-6