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The value of primary tumor 18F-FDG uptake on preoperative PET/CT for predicting intratumoral lymphatic invasion and axillary nodal metastasis

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Abstract

Background

The preoperative evaluation of axillary lymph node (LN) status is important for prognostic prediction of breast cancer. We investigated the ability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict intratumoral lymphatic invasion and axillary LN metastasis.

Methods

The preoperative 18F-FDG PET/CT images and pathologic reports for 428 breast cancer patients between January 2003 and December 2008 were evaluated retrospectively. The maximum standardized uptake value (SUVmax) of the primary tumor on 18F-FDG PET/CT, the degree of lymphatic invasion, and axillary LN metastasis identified by pathologic reports were assessed. Univariate and multivariate logistic regression analyses were performed to identify the significant features of the primary tumor that were associated with pathologically confirmed axillary LN metastasis.

Results

The mean SUVmax of primary tumors with lymphatic invasion was higher than that of tumors without lymphatic invasion (5.13 ± 3.49 vs. 3.00 ± 2.47; p < 0.0001). The mean SUVmax of primary tumors with pathologically confirmed axillary LN metastasis was higher than that of tumors without LN metastasis (4.93 ± 3.32 vs. 3.22 ± 2.78; p < 0.0001). The degree of lymphatic invasion correlated strongly with axillary LN metastasis (p = 0.0001). Multiple logistic regression analysis showed that the high SUVmax of the primary tumor (>2.8), the high SUVmax of the axillary LN (>0.72) and the degree of lymphatic invasion were significant predictive factors of the development of axillary LN metastasis.

Conclusion

Breast cancer patients with higher primary tumor 18F-FDG uptake are at higher risk of concurrent intratumoral lymphatic invasion and axillary LN metastasis.

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Authors and Affiliations

  1. Department of Radiology, College of Medicine, Bucheon St. Mary’s Hospital, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, Bucheon, Gyeonggi-do, 420-717, Republic of Korea

    Na Young Jung & Myung Hee Chung

  2. Department of Radiology, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Republic of Korea

    Sung Hoon Kim, Bong Joo Kang & Sonya Youngju Park

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  1. Na Young Jung
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  2. Sung Hoon Kim
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  5. Myung Hee Chung
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Correspondence to Sung Hoon Kim.

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Jung, N.Y., Kim, S.H., Kang, B.J. et al. The value of primary tumor 18F-FDG uptake on preoperative PET/CT for predicting intratumoral lymphatic invasion and axillary nodal metastasis. Breast Cancer 23, 712–717 (2016). https://doi.org/10.1007/s12282-015-0629-4

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  • DOI: https://doi.org/10.1007/s12282-015-0629-4

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