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Phototriggered targeting of nanocarriers for drug delivery

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Abstract

Stimuli-triggered targeting of drug delivery systems can both increase the therapeutic efficacy and lower toxicity by selectively delivering drugs at target sites with high specificity and efficiency. Light is a convenient and powerful stimulus for use in such drug delivery systems because it is readily available and noninvasive and offers excellent spatiotemporal control. The power and wavelength of light can be finely tuned for different photoresponsive systems to achieve efficient targeting at the tissue, cellular, or subcellular levels. Here, we have reviewed the various mechanisms for phototriggered targeting (phototargeting) of drug nanocarriers. We have discussed the three main phototargeting strategies: (1) targeting ligand activation; (2) particle size reduction; and (3) blood vessel disruption.

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Acknowledgements

We gratefully acknowledge financial support from Dr. Li Dak-Sum Research Fund (Start-up Fund) of The University of Hong Kong and Seed Fund for Basic Research of The University of Hong Kong (Nos. 201704159010 and 201711159053).

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  1. Dr. Li Dak-Sum Research Centre, The University of Hong Kong-Karolinska Institutet Collaboration in Regenerative Medicine, The University of Hong Kong, Hong Kong, China

    Yafei Li, Yaming Zhang & Wei** Wang

  2. Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China

    Yafei Li, Yaming Zhang & Wei** Wang

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  1. Yafei Li
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  2. Yaming Zhang
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  3. Wei** Wang
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Correspondence to Wei** Wang.

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Li, Y., Zhang, Y. & Wang, W. Phototriggered targeting of nanocarriers for drug delivery. Nano Res. 11, 5424–5438 (2018). https://doi.org/10.1007/s12274-018-2132-7

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  • DOI: https://doi.org/10.1007/s12274-018-2132-7

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