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Two new quinones from the roots of Juglans mandshurica

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Abstract

Two new quinones, 1-hydroxy-5-pentyl-anthraquinone (1) and 4-(5-hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-butyric acid methyl ester (2), together with two known quinones, 5-hydroxy-2-(2-hydroxy-ethylamino)-(1,4) naphthoquinone (3) and juglone (4) were isolated from the roots of Juglans mandshurica (Juglandaceae). Their structures were elucidated on the basis of spectral data. Compound 3 was isolated from the Juglans genus for the first time. Compounds 1–4 exhibited significant cytotoxicity towards cultured MDA-MB231, HepG2 and SNU638 cells with IC50 values ranging from 4.46 to 88.47 μM.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China under Grant numbers 81160386, 81260474, and 30911140276. This work was also partially supported by Jilin Provincial Science & Technology Department under Grant number 20140101037JC.

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Authors and Affiliations

  1. Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji, 133002, People’s Republic of China

    Mei **, **feng Sun, Shengbao Diao, Changhao Zhang, Jiongmo Cui, Wei Zhou & Gao Li

  2. Department of Pharmacy, Yanbian University Hospital, Yanji, 133000, China

    Mei ** & Ren Li

  3. College of Pharmacy, Yeungnam University, Gyongsan, 712-749, Korea

    Jong-Keun Son

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  1. Mei **
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  2. **feng Sun
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  3. Ren Li
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  4. Shengbao Diao
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  5. Changhao Zhang
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  8. Wei Zhou
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  9. Gao Li
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Correspondence to Wei Zhou or Gao Li.

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**, M., Sun, J., Li, R. et al. Two new quinones from the roots of Juglans mandshurica . Arch. Pharm. Res. 39, 1237–1241 (2016). https://doi.org/10.1007/s12272-016-0781-1

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  • DOI: https://doi.org/10.1007/s12272-016-0781-1

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