Abstract
Phytochemical investigation of the ethanol extract of the roots of Sanguisorba officinalis resulted in the isolation of three new triterpene glycosides, 3β-[(α-L-arabinopyranosyl)oxy]-19α,23-dihydroxyolean-12-en-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (1), 2α,3β,19α,23-tetrahydroxyurs-12-en-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (2), and 3β-[(α-L-arabinopyranosyl)oxy]-19α-hydroxyurs-12,20(30)-dien-28-oic acid 28-[6-O-acetyl-β-D-glucopyranosyl] ester (3). All the triterpene glycosides exhibited the significant cytotoxic potential with low IC50 values (IC50 < 5.0 μM) against six tumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCI-H460, and BGC-823).
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The above research was made possible by the grant from the Scientific Planning Project of the Applied Basic Research of Yunnan Province (S2012FZ0005) and the Develo** Key Subject of Ecology of Qu**g Normal University.
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Jiang Hu and Yan Song have contributed equally to this work.
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Hu, J., Song, Y., Li, H. et al. Cytotoxic triterpene glycosides from the roots of Sanguisorba officinalis . Arch. Pharm. Res. 38, 984–990 (2015). https://doi.org/10.1007/s12272-014-0477-3
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DOI: https://doi.org/10.1007/s12272-014-0477-3