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Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma

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Abstract

Peripheral T cell lymphoma not otherwise specified (PTCL-N) and ALK-negative anaplastic large cell lymphoma (ALCL) are heterogeneous categories with poor diagnostic reproducibility. To clarify the biologic features of these categories, we investigated the expression of two chemokine receptors, type 1 (Th1/Tc1)-associated CXCR3 and type 2 (Th2/Tc2)-associated CCR4 in 110 PTCL-N and 35 ALK-negative ALCL cases, as well as the expression of cytotoxic molecules (CM). CXCR3 and CCR4 were expressed in 69 (63%) and 37 (34%) of PTCL-N, and in 12 (34%) and 6 (17%) of ALK-negative ALCL, respectively. In PTCL-N, type 1 pattern (CXCR3+CCR4−) was dominant (52%), whereas in ALK-negative ALCL, 54% were negative for both (P < 0.0001). CM was expressed in 38% of PTCL-N and 51% of ALK-negative ALCL. CM-positive PTCL-N consisted mostly of type 1 disease, which shows type 1 phenotype. In contrast, type 2 pattern (CXCR3−CCR4+) was recognized in the CM-negative group only. Among type 1 disease, CM-positive cases had a higher female ratio and more aggressive clinical features than CM-negative cases and a poorer prognosis (P = 0.006). Multivariate analysis confirmed that the type 1 phenotype with CM expression was an independent prognostic factor. In both PTCL-N and ALK-negative ALCL, CM-positive type 1 disease had an extremely poor prognosis.

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Acknowledgments

The authors thank H. Ishida for technical assistance, and collaborators from the following institutions for their provision of clinical data and specimens: Asahikawa Red Cross Hospital, Akita University School of Medicine, Tohoku University School of Medicine, Sendai City Hospital, Ohta Nishinouchi General Hospital, Red Cross Ashikaga Hospital, Gunma University School of Medicine, Kitazato University School of Medicine, Tsukuba University School of Medicine, Saitama Cancer Center, Chiba University School of Medicine, Takeda General Hospital, Tokyo Women’s Medical University Daini Hospital, Matsudo Municipal Hospital, Higashi Matsudo Hospital, Niigata University, Nagano Red Cross Hospital, Shinshu University School of Medicine, Iida Municipal Hospital, Toyama Central Hospital, Kanazawa Medical University, Fukui Red Cross Hospital, Seirei Hamamatsu Hospital, Hamamatsu Medical School, Toyohashi Municipal Hospital, Aichi Prefectural Hospital, Toyota Memorial Hospital, Fujita Health University School of Medicine, Okazaki Municipal Hospital, Kariya General Hospital, Tousei Hospital, Tokoname Municipal Hospital, Ichinomiya Municipal Hospital, Kasugai Municipal Hospital, Japanese Red Cross Nagoya First Hospital, Nagoya Memorial Hospital, Nagoya City University School of Medicine, Aichi Cancer Center, Showa Hospital, Yokkaichi Municipal Hospital, Suzuka Chuo General Hospital, Suzuka Kaisei General Hospital, Mie University School of Medicine, Yamada Red Cross Hospital, Ise City General Hospital, Kyoto University, Kyoto Prefectural University School of Medicine, Okayama University Medical School, Okayama Red Cross General Hospital, Kawasaki Medical School, Matsue Red Cross Hospital, Japanese Red Cross Takamatsu Hospital, Fukuoka University School of Medicine, Kyushu Cancer Center, Kyushu University, and Kurume University.

Conflict of interest statement

The authors have no potential conflicts of interest.

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Author notes

  1. Naoko Asano

    Present address: Department of Laboratory Medicine, Shinshu University, 3-1-1 Asahi, Matsumoto, 390-8621, Japan

Authors and Affiliations

  1. Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan

    Naoko Asano

  2. Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Nagoya, Japan

    Yoshitoyo Kagami & Yasuo Morishima

  3. Department of HSCT Data Management, Nagoya University Hospital, Nagoya, Japan

    Ritsuro Suzuki

  4. Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya, Japan

    Shigeo Nakamura

  5. Department of Pathology, Kurume University, Kurume, Japan

    Koichi Ohshima

  6. Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan

    Naoko Asano & Fumihiro Ishida

  7. Department of Pathology, Okayama University, Okayama, Japan

    Tadashi Yoshino

  8. Department of Pathology, Seirei Mikatahara General Hospital, Hamamatsu, Japan

    Hiroshi Ogawa

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  1. Naoko Asano
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Correspondence to Naoko Asano.

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Asano, N., Suzuki, R., Ohshima, K. et al. Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell lymphoma. Int J Hematol 91, 426–435 (2010). https://doi.org/10.1007/s12185-010-0513-0

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