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Diagnostic Reliability of CRTC1/3::MAML2 Gene Fusion Transcripts in Discriminating Histologically Similar Intraosseous Mucoepidermoid Carcinoma from Glandular Odontogenic Cyst: A Systematic Review and Meta-analysis

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Abstract

Background

Intraosseous mucoepidermoid carcinoma (IMEC) and Glandular odontogenic cyst (GOC) are those two pathological entities causing diagnostic dilemma due to the histopathological similarity. An accurate distinction between the two entities is difficult as both presents with a common radiological and histological similarities. The aim of our systematic review was to establish the diagnostic reliability of CRTC1/3::MAML2 gene fusion for the distinction between IMEC and GOC.

Methods

A complete electronic literature search was made in MEDLINE by PubMed, Google Scholar, and EMBASE databases. Articles with keywords using molecular genetic findings of CRTC1/3::MAML2 gene fusion transcripts, IMEC and GOC were assessed and included for the systematic review.

Results

Twelve subgroups having both qualitative and quantitative analysis revealed CRTC1/3::MAML2 sensitivity of 100% and specificity of 70.59% in differentiating GOC and IMEC. Fixed-effects model confirmed translocation-negative cases to have a decreased risk of association with IMEC (combined odds ratio 8.770, 95% confidence interval − 2.45 to 31.45, p < 0.002).

Conclusions

The current evidence supports that in all cases with positive gene fusion transcript of the CRTC1/3::MAML2 was specific for IMEC and was significantly differentiating it from GOC. Whereas cases of IMEC with negative gene fusion transcript pose diagnostic difficulty in differentiating from a GOC which is negative for CRTC1/3::MAML2 expression.

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Data Availability

Articles including intraosseous mucoepidermoid carcinoma and glandular odontogenic cyst with studies on CRTC1::MAML2 OR CRTC3::MAML2 OR MAML2 OR TORC1 OR MECT1 OR WAMPT1 gene transcripts examined in databases of MEDLINE by PubMed, Google scholar, Scopus, Trip, Cochrane library and EMBASE until 31st January 2022, without period restriction.

Code Availability

All statistical analyses were performed using Microsoft Excel worksheet and SPSS Statistics for Windows Version 25.0 (IBM Corp., Armonk, New York, USA).

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Authors and Affiliations

  1. Department of Oral Maxillofacial Pathology and Microbiology, Post Graduate Institute of Dental Sciences (PGIDS), Rohtak, Haryana, 124001, India

    R. Keerthika, Anju Devi, Mala Kamboj, Gopikrishnan Vijayakumar, Anjali Narwal & Akhil Girdhar

  2. Department of Oral and Maxillofacial Pathology & Microbiology, King George’s Medical University, Lucknow, Uttar Pradesh, 226003, India

    N. Sivakumar

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  1. R. Keerthika
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Correspondence to R. Keerthika.

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Keerthika, R., Devi, A., Kamboj, M. et al. Diagnostic Reliability of CRTC1/3::MAML2 Gene Fusion Transcripts in Discriminating Histologically Similar Intraosseous Mucoepidermoid Carcinoma from Glandular Odontogenic Cyst: A Systematic Review and Meta-analysis. Head and Neck Pathol 17, 233–245 (2023). https://doi.org/10.1007/s12105-022-01494-x

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