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The endothelial tip-stalk cell selection and shuffling during angiogenesis

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Journal of Cell Communication and Signaling Aims and scope

Abstract

Angiogenesis is a critical, fine-tuned, multi-staged biological process. Tip-stalk cell selection and shuffling are the building blocks of sprouting angiogenesis. Accumulated evidences show that tip-stalk cell selection and shuffling are regulated by a variety of physical, chemical and biological factors, especially the interaction among multiple genes, their products and environments. The classic Notch-VEGFR, Slit-Robo, ECM-binding integrin, semaphorin and CCN family play important roles in tip-stalk cell selection and shuffling. In this review, we outline the progress and prospect in the mechanism and the roles of the various molecules and related signaling pathways in endothelial tip-stalk cell selection and shuffling. In the future, the regulators of tip-stalk cell selection and shuffling would be the potential markers and targets for angiogenesis.

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Acknowledgments

This study was funded by the National Natural Science Foundation of China (Grant No. 31201052, 81802815). We thank Man Lu and Huiyu Li for polishing the manuscript.

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  1. Wenqi Chen, Peng ** Wang, Jihao Tu and ** Wang

  2. The First Hospital of Jilin University, Changchun, China

    **nyue Liang & **aoling Zhang

  3. Institute of Immunology, Jilin University, Changchun, China

    **aoling Zhang

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Chen, W., **a, P., Wang, H. et al. The endothelial tip-stalk cell selection and shuffling during angiogenesis. J. Cell Commun. Signal. 13, 291–301 (2019). https://doi.org/10.1007/s12079-019-00511-z

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