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Review of microRNA in osteosarcoma and chondrosarcoma

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Abstract

MicroRNAs (miRNAs) are small noncoding RNAs, which play a complex role in posttranscriptional gene expression and can theoretically be used as a diagnostic or prognostic tool, or therapeutic target for neoplasia. Despite advances in the diagnosis and treatment of skeletal sarcomas, including osteosarcoma and chondrosarcoma, much remains unknown regarding their underpinning molecular mechanisms. Given the recent increasing knowledge base of miRNA roles in neoplasia, both as oncogenes and tumor suppressor genes, this review will focus on the available literature regarding the expression profiles and potential roles of miRNA in skeletal sarcomas. Although this is an emerging field, miRNA profiling may be of use in clarifying competing diagnoses of skeletal sarcomas and possibly indicate patient risk of resistance to traditional chemotherapeutic agents. While detecting and targeting miRNAs is currently limited to experimental investigations, miRNA may be utilized for future clinical management of skeletal sarcomas.

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Acknowledgments

The present work was supported by the UCLA Department of Pathology and Laboratory Medicine, the Translational Research Fund and the UCLA Daljit S. and Elaine Sarkaria Fellowship award. The authors thank the staff of UCLA Translational Pathology Core Laboratory and A.S. James for their excellent technical assistance.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave., 13-145 CHS, Los Angeles, CA, 90095, USA

    Le Chang, Swati Shrestha, Greg LaChaud & Aaron W. James

  2. Nationwide Children’s Hospital, Columbus, OH, 43205, USA

    Michelle A. Scott

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  1. Le Chang
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  2. Swati Shrestha
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  3. Greg LaChaud
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Correspondence to Aaron W. James.

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Chang, L., Shrestha, S., LaChaud, G. et al. Review of microRNA in osteosarcoma and chondrosarcoma. Med Oncol 32, 172 (2015). https://doi.org/10.1007/s12032-015-0613-z

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