Abstract
Post-stroke cognitive impairment (PSCI), as one of the major complications after stroke, refers to a series of syndromes from mild cognitive impairment to dementia caused by stroke. Stroke has been reported to increase the risk of cognitive impairment by at least five to eight times. The assessment of PSCI usually relies on neuropsychological tests, but the results of these tests are subjective and inaccurate, and can be insufficient for the diagnosis and prognosis of PSCI. In recent years, an increasing number studies have indicated that changes in the expression of biomarkers such as C-reactive protein (CRP), interleukin 6 (IL-6) and IL-10 in blood, urine and other body fluids are associated with cognitive decline after stroke. Therefore, the detection of biomarkers in circulating blood serum, plasma and cerebrospinal fluid (CSF) may improve the accuracy of diagnosis and prognosis in PSCI. This review aims to summarize the studies on potential molecular biomarkers of PSCI.
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Abbreviations
- MMSE:
-
Mini-Mental State Examination
- MoCA:
-
Montreal Cognitive Assessment
- SD:
-
Standard deviation
- T3:
-
Triiodothyronine
- RF:
-
Rheumatoid factor
- OR:
-
Odds ratio
- 95% CI:
-
95% Confidence interval
- MMP-9:
-
Matrix metalloproteinase-9
- tHcy:
-
Total homocysteine
- CI:
-
Cognitive impairment
- VCIND:
-
Vascular cognitive impairment with no dementia
- VD:
-
Vascular dementia
- Hcy:
-
Homocysteine
- hs-CRP:
-
High-sensitivity C-reactive protein
- IL:
-
Interleukin
- CSF:
-
Cerebrospinal fluid
- PSND:
-
Post-stroke none-demented
- PSD:
-
Post-stroke dementia
- VaD:
-
Vascular dementia
- AD:
-
Alzheimer’s Disease
- SAA:
-
Serum amyloid A
- NCI:
-
No cognitive impairment
- CIND:
-
Cognitive impairment no dementia
- T3:
-
Triiodothyronine
- ICAS:
-
Intracranial arterial stenosis
- NT-proBNP:
-
N-terminal pro-B-type natriuretic peptide
- PSCI:
-
Post-stroke cognitive impairment
- 8-OhdG:
-
8-Hydroxydeoxyguanosine
- MDA:
-
Malondialdehyde
- CoQ10:
-
Coenzyme Q10
- BDNF:
-
Brain-derived neurotrophic factor
- IGF-1:
-
Insulin-like growth factor–1;VCI, vascular cognitive impairment
- CST3:
-
cystatin C gene
- TMAO:
-
Trimethylamine-N-oxide
- RA:
-
Retinoic acid
- PSNCI:
-
Post-stroke non-cognitive impairment
- AUC:
-
area under curve
- PSCN:
-
Post-stroke cognitive normality
- miR-132:
-
microRNA-132
- ROC:
-
Receiver operating characteristic
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This work was supported by funding from scientific research of Shanghai Municipal Health Bureau (201940031) and the Leading Personnel Training Project of Shanghai Pudong New District Municipal Health Bureau (No. PWR12018-04).
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**nxin Zhang designed the article contents and wrote the original manuscript. **a Bi made revisions to the manuscript and provided financial support.
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Zhang, X., Bi, X. Post-Stroke Cognitive Impairment: A Review Focusing on Molecular Biomarkers. J Mol Neurosci 70, 1244–1254 (2020). https://doi.org/10.1007/s12031-020-01533-8
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DOI: https://doi.org/10.1007/s12031-020-01533-8