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Radiation Therapy Is Associated With Fewer Recurrences in Mesenchymal Chondrosarcoma

  • Symposium: Musculoskeletal Tumor Society 2012 Symposium
  • Published:
Clinical Orthopaedics and Related Research®

Abstract

Background

Mesenchymal chondrosarcoma (MSC) is a rare variant of chondrosarcoma. Because of the rarity of the disease, most studies only contain a small number of patients and thus the prognostic variables and role of adjuvant therapies remain controversial.

Questions/purposes

We therefore asked (1) what the overall and disease-free survival were for patients with this diagnosis at 5 and 10 years; (2) whether there were significant prognostic factors associated with survival; and (3) whether use of adjuvant chemotherapy or radiotherapy was associated with survival in patients with MSC.

Methods

We retrospectively reviewed the cases of MSC diagnosed from 1979 to 2010 at one referral center. Forty-three cases were identified. Thirty-seven cases were analyzed for demographics, treatments, and outcomes. Thirty patients with localized disease were analyzed for prognostic factors. The minimum followup was 1 month (mean, 6 years; range, 1 month to 17 years). There were 17 females and 20 males. The mean age at diagnosis was 33 years (range, 11–65 years). Nineteen cases were skeletal and 18 cases were extraskeletal. Seventy-six percent of the tumors were located in the trunk.

Results

Five- and 10-year overall survival was 51% and 37%, respectively. Five- and 10-year disease-free survival was 23% and 5%, respectively. Age (< 30 years) and male sex were associated with poorer overall and disease-free survival in patients presenting with a localized tumor, respectively. Patients who did not receive radiotherapy were more likely to have a local recurrence. Adjuvant chemotherapy failed to show a significant association with overall, disease-free, metastasis-free, or local recurrence-free survival.

Conclusions

The present study reinforced the role of adjuvant radiotherapy for local tumor control.

Level of Evidence

Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

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Author information

Authors and Affiliations

  1. Department of Orthopaedic Oncology, The University of Texas MD Anderson Cancer, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    Satoshi Kawaguchi MD, Patrick P. Lin MD & Valerae O. Lewis MD

  2. Sheba Medical Center, Raanana, Israel

    Israel Weiss MD

  3. Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Winston W. Huh MD

Authors
  1. Satoshi Kawaguchi MD
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  2. Israel Weiss MD
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  3. Patrick P. Lin MD
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  4. Winston W. Huh MD
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  5. Valerae O. Lewis MD
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Corresponding author

Correspondence to Valerae O. Lewis MD.

Additional information

Each author certifies that he or she, or a member of his or her immediate family, has no funding or commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article.

All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research ® editors and board members are on file with the publication and can be viewed on request.

Each author certifies that his or her institution approved the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained.

Clinical Orthopaedics and Related Research ® neither advocates nor endorses the use of any treatment, drug, or device. Readers are encouraged to always seek additional information, including FDA approval status, of any drug or device prior to clinical use.

This work was performed at the University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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Kawaguchi, S., Weiss, I., Lin, P.P. et al. Radiation Therapy Is Associated With Fewer Recurrences in Mesenchymal Chondrosarcoma. Clin Orthop Relat Res 472, 856–864 (2014). https://doi.org/10.1007/s11999-013-3064-x

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  • DOI: https://doi.org/10.1007/s11999-013-3064-x

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