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Novel Assessment Tools for Osteoporosis Diagnosis and Treatment

  • Bone Quality in Osteoporosis (MD Grynpas and JS Nyman, Section Editors)
  • Published:
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Abstract

This review describes new technologies for the diagnosis and treatment, including fracture risk prediction, of postmenopausal osteoporosis. Four promising technologies and their potential for clinical translation and basic science studies are discussed. These include reference point indentation (RPI), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and magnetic resonance imaging (MRI). While each modality exploits different physical principles, the commonality is that none of them require use of ionizing radiation. To provide context for the new developments, brief summaries are provided for the current state of biomarker assays, fracture risk assessment (FRAX), and other fracture risk prediction algorithms and quantitative ultrasound (QUS) measurements.

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Conflict of Interest

B. Gong, G.S. Mandair, and F.W. Wehrli all declare that they have no conflicts of interest. M.D. Morris has received research support from the National Institutes of Health; consultant fees from Kaiser Optical Systems, Inc.; and is a member of Biomatrix Photonics, LLC.

Human and Animal Rights and Informed Consent

All studies by B. Gong, G.S. Mandair, and M.D. Morris involving animal and/or human subjects were performed after approval by the appropriate institutional review boards. When required, written informed consent was obtained from all participants.

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Authors and Affiliations

  1. Department of Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA

    Bo Gong, Gurjit S. Mandair & Michael D. Morris

  2. Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Felix W. Wehrli

Authors
  1. Bo Gong
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  2. Gurjit S. Mandair
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  3. Felix W. Wehrli
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  4. Michael D. Morris
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Corresponding author

Correspondence to Michael D. Morris.

Additional information

B. Gong and G. S. Mandair contributed equally to this work.

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Gong, B., Mandair, G.S., Wehrli, F.W. et al. Novel Assessment Tools for Osteoporosis Diagnosis and Treatment. Curr Osteoporos Rep 12, 357–365 (2014). https://doi.org/10.1007/s11914-014-0215-2

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