Log in

The Approach to the Psychosocial Evaluation of Cardiac Transplant and Mechanical Circulatory Support Candidates

  • Nonpharmacologic Therapy: Surgery, Ventricular Assist Devices, Biventricular Pacing, and Exercise (A Hasan, Section Editor)
  • Published:
Current Heart Failure Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

We update evidence underlying the recommendations of a 2018 multi-society consensus report regarding the psychosocial evaluation of individuals for cardiothoracic transplantation and mechanical circulatory support (MCS). In the present review, we focus on heart transplantation and MCS.

Recent Findings

Expert opinion and new evidence support the inclusion of ten core content areas in the psychosocial evaluation. Prospective data indicate that psychosocial factors can predict post-transplantation/post-implantation outcomes. Such factors include treatment adherence history, mental health and substance use history, cognitive impairment, knowledge about treatment options, and social factors such as socioeconomic status. For other factors (e.g., co**, social support), new evidence is weaker because it derives largely from cross-sectional studies. Concerning evaluation process issues, expert opinion remains consistent with consensus recommendations, but there is a dearth of empirical evidence.

Summary

The psychosocial evaluation can identify factors relevant for candidacy for heart transplantation and MCS implantation. It enables the provision of interventions to improve patients’ viability as candidates, and facilitates care planning.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. •• Dew MA, DiMartini AF, Dobbels F, Grady KL, Jowsey-Gregoire SG, Kaan A, et al. The 2018 ISHLT/APM/AST/ICCAC/STSW recommendations for the psychosocial evaluation of adult cardiothoracic transplant candidates and candidates for long-term mechanical circulatory support. J Heart Lung Transplant. 2018;37(7):803–23 This document was developed by 27 representatives from five major societies and is the first set of consensus-based recommendations regarding the psychosocial evaluation in cardiothoracic transplantation and mechanical circulatory support. A total of 61 recommendations address both the content and process of conducting and reporting on the psychosocial evaluation.

    Article  Google Scholar 

  2. Mehra MR, Canter CE, Hannan MM, Semigran MJ, Uber PA, Baran DA, et al. The 2016 International Society for Heart and Lung Transplantation listing criteria for heart transplantation: a 10-year update. J Heart Lung Transplant. 2016;35:1–23.

    Article  Google Scholar 

  3. Weill D, Benden C, Corris PA, Dark JH, Davis RD, Keshavjee S, et al. A consensus document for the selection of lung transplant candidates:2014—an update from the Pulmonary Transplantation Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2015;34:1–15.

    Article  Google Scholar 

  4. Feldman D, Pamboukian SV, Teuteberg JJ, Birks E, Lietz K, Moore SA, et al. The 2013 International Society for Heart and Lung Transplantation guidelines for mechanical circulatory support: executive summary. J Heart Lung Transplant. 2013;32:157–87.

    Article  Google Scholar 

  5. Cook JL, Colvin M, Francis GS, Grady KL, Hoffman TM, Jessup M, et al. Recommendations for the use of mechanical circulatory support: ambulatory and community patient care: a scientific statement from the American Heart Association. Circ. 2017;135(25):e1145–58.

    Article  Google Scholar 

  6. Kröncke S, Greif-Higer G, Albert W, de Zwaan M, Erim Y, Eser-Valeri D, et al. Psychosoziale evaluation von transplantationspatienten – empfehlungen für die richtlinien zur organtransplantation [Psychosocial evaluation of transplant patients - recommendations for the guidelines for organ transplantation]. Psychother Psychosom Med Psychol. 2018;68(5):179–84.

    Article  Google Scholar 

  7. Maldonado JR. The psychosocial evaluation of transplant candidates. In: Sher Y, Maldonado J, editors. Psychosocial care of end-stage organ disease and transplant patients. Cham, Switzerland: Springer; 2019. p. 17–48.

    Chapter  Google Scholar 

  8. Newman L. The psychosocial treadmill: the road to improving high-risk behavior in advanced therapy candidates. Curr Heart Fail Rep. 2018;15(2):70–4.

    Article  Google Scholar 

  9. Sher Y, Zimbrean P. Psychiatric aspects of organ transplantation in critical care: an update. Crit Care Clin. 2017;33(3):659–79.

    Article  Google Scholar 

  10. • Tumin D, McConnell PI, Galantowicz M, Tobias JD, Hayes D Jr. Reported nonadherence to immunosuppressive medication in young adults after heart transplantation: a retrospective analysis of a national registry. Transplantation. 2017;101(2):421–9 This report considers national data in the USA and explores the combination of age and nonadherence in predicting survival after heart transplantation. It is an important addition to the literature examining the increased risk for nonadherence in older adolescents and young adults.

    Article  Google Scholar 

  11. • Lundgren S, Lowes BD, Zolty R, Burdorf A, Raichlin E, Um JY, et al. Do psychosocial factors have any impact on outcomes after left ventricular assist device implantation? ASAIO J. 2018;64(4):e43–7 This report is among the most comprehensive in terms of the range of pre-implantation psychosocial factors considered as potential predictors of post-implantation clinical outcomes.

    Article  Google Scholar 

  12. Vitinius F, Reklat A, Hellmich M, Klask E, Wahlers T, Rahmanian PB, et al. Prediction of survival on the waiting list for heart transplantation and of posttransplant nonadherence: results of a prospective longitudinal study. Clin Transpl. 2019;33(7):e13616. https://doi.org/10.1111/ctr.13616.

    Article  Google Scholar 

  13. Delibasic M, Mohamedali B, Dobrilovic N, Raman J. Pre-transplant depression as a predictor of adherence and morbidities after orthotopic heart transplantation. J Cardiothorac Surg. 2017;12(1):62. https://doi.org/10.1186/s13019-017-0626-0.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Epstein F, Parker MM, Lucero A, Chaudhary R, Song E, Weisshaar D. Association of depression and anxiety before heart transplant with mortality after transplant: a single-center experience. Transplant Res Risk Manag. 2017;9:31–8.

    Article  Google Scholar 

  15. Kaiser JA. Readmissions after left ventricular assist device implantation: considerations for nurse practitioners. J Am Assoc Nurse Pract. 2019;31(7):396–402.

    PubMed  Google Scholar 

  16. Lundgren S, Poon CYM, Selim A, Lowes BD, Zolty R, Burdorf A, et al. Depression and anxiety in patients undergoing left ventricular assist device implantation. Int J Artif Organs. 2018;41(2):76–83.

    Article  Google Scholar 

  17. Sözen F, Çetinel Y, Kul ÖE, Sezgin A. Smoking behavior of heart transplant patients: a retrospective study. Exp Clin Transplant. 2018;16(Suppl 1):162–4.

    PubMed  Google Scholar 

  18. •• Hofmann P, Benden C, Kohler M, Schuurmans MM. Smoking resumption after heart or lung transplantation: a systematic review and suggestions for screening and management. J Thorac Dis. 2018;10(7):4609–18 An important new systematic review that considers the range of evidence available on tobacco smoking and cardiothoracic transplantation.

    Article  Google Scholar 

  19. Ambardekar AV, Thibodeau JT, DeVore AD, Kittleson MM, Forde-McLean RC, Palardy M, et al. Discordant perceptions of prognosis and treatment options between physicians and patients with advanced heart failure. JACC Heart Fail. 2017;5(9):663–71.

    Article  Google Scholar 

  20. •• Kostick KM, Bruce CR, Minard CG, Volk RJ, Vivitello A, Krim SR, et al. A multisite randomized controlled trial of a patient-centered ventricular assist device decision aid (VADDA trial). J Card Fail. 2018;24(10):661–71 Important because it is one of the very few randomized clinical trials examining strategies to improve decision-making in patients who are candidates for MCS.

    Article  Google Scholar 

  21. Buchberg Trejo M, Kostick KM, Estep JD, Blumenthal-Barby JS. Identifying knowledge gaps among LVAD candidates. J Clin Med. 2019;8(4):E549. https://doi.org/10.3390/jcm8040549.

    Article  PubMed  Google Scholar 

  22. •• Allen LA, McIlvennan CK, Thompson JS, Dunlay SM, LaRue SJ, Lewis EF, et al. Effectiveness of an intervention supporting shared decision making for destination therapy left ventricular assist device: the DECIDE-LVAD randomized clinical trial. JAMA Intern Med. 2018;178(4):520–9 This report is one of the very few clinical trials examining strategies to improve decision-making in patients who are candidates for MCS. It goes beyond examining patient knowledge to consider other indicators of improved decision-making.

    Article  Google Scholar 

  23. Magasi S, Buono S, Yancy CW, Ramirez RD, Grady KL. Preparedness and mutuality affect quality of life for patients with mechanical circulatory support and their caregivers. Circ Cardiovasc Qual Outcomes. 2019;12(1):e004414. https://doi.org/10.1161/CIRCOUTCOMES.117.004414.

    Article  PubMed  Google Scholar 

  24. Wilhelm LA, Blumenthal-Barby JS, Kostick KM, Estep JD, Bruce CR. Patients’ perspectives on transplantation while undergoing left ventricular assist device support. ASAIO J. 2017;63(6):740–4.

    Article  Google Scholar 

  25. Miliniak I, Wilczek-Rużyczka E, Wierzbicki K, Piątek J, Kapelak B, Przybyłowski P. Relationship between satisfaction with social support and self-efficacy and the occurrence of depressive symptoms and stress in heart transplant recipients. Transplant Proc. 2018;50(7):2113–8.

    Article  Google Scholar 

  26. Abshire M, Russell SD, Davidson PM, Budhathoki C, Han HR, Grady KL, et al. Social support moderates the relationship between perceived stress and quality of life in patients with a left ventricular assist device. J Cardiovasc Nurs. 2018;33(5):e1–9.

    Article  Google Scholar 

  27. Denhaerynck K, Berben L, Dobbels F, Russell CL, Crespo-Leiro MG, Poncelet AJ, et al. Multilevel factors are associated with immunosuppressant nonadherence in heart transplant recipients: the international BRIGHT study. Am J Transplant. 2018;18(6):1447–60.

    Article  Google Scholar 

  28. • Bidwell JT, Lyons KS, Mudd JO, Grady KL, Gelow JM, Hiatt SO, et al. Patient and caregiver determinants of patient quality of life and caregiver strain in left ventricular assist device therapy. J Am Heart Assoc. 2018;7(6):e008080. https://doi.org/10.1161/JAHA.117.008080Noteworthy because it is the only new study to provide prospective data (rather than only cross-sectional data) on associations between characteristics of social support and pre- to post-implantation change in patient HRQOL.

    Article  PubMed  PubMed Central  Google Scholar 

  29. •• Ladin K, Daniels A, Osani M, Bannuru RR. Is social support associated with post-transplant medication adherence and outcomes? a systematic review and meta-analysis. Transplant Rev (Orlando). 2018;32(1):16–28 An important and thorough systematic review that not only considers overall effect sizes but examines effect sizes within key subgroups of patients (e.g., those receiving heart transplants, those receiving each of several other types of transplants).

    Article  Google Scholar 

  30. • Wayda B, Clemons A, Givens RC, Takeda K, Takayama H, Latif F, et al. Socioeconomic disparities in adherence and outcomes after heart transplant: UNOS (United Network for Organ Sharing) registry analysis. Circ Heart Fail. 2018;11(3):e004173. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004173This report examines national data and is able to provide more definitive evidence than most previous reports on the association of socioeconomic status with clinical outcomes after heart transplantation, as well as the association of race with these outcomes in the USA. Medication nonadherence was considered as a secondary outcome and was not directly assessed.

    Article  PubMed  Google Scholar 

  31. Breathett K, Willis S, Foraker RE, Smith S. Impact of insurance type on initial rejection post heart transplant. Heart Lung Circ. 2017;26(2):164–71.

    Article  Google Scholar 

  32. Ahmed MM, Magar SM Jr, Jeng EI, Arnaoutakis GJ, Beaver TM, Vilaro J, et al. Effects of socioeconomic status on clinical outcomes with ventricular assist devices. Clin Cardiol. 2018;41(11):1463–7.

    Article  Google Scholar 

  33. Clemons AM, Flores RJ, Blum R, Wayda B, Brunjes DL, Habal M, et al. Effect of socioeconomic status on patients supported with contemporary left ventricular assist devices. ASAIO J. 2019. https://doi.org/10.1097/MAT.0000000000001009.

  34. Chisholm-Burns MA, Spivey CA, Pickett LR. Health literacy in solid-organ transplantation: a model to improve understanding. Patient Prefer Adherence. 2018;12:2325–38.

    Article  Google Scholar 

  35. Breathett K. Same story, different disease. It is time to change the storyline for racial minorities and patients of lower socioeconomic status. Circ Heart Fail. 2018;11:e004931. https://doi.org/10.1161/CIRCHEARTFAILURE.118.004931.

    Article  PubMed  PubMed Central  Google Scholar 

  36. • Ravi Y, Lella SK, Copeland LA, Zolfaghari K, Grady K, Emani S, et al. Does recipient work status pre-transplant affect post-heart transplant survival? a United Network for Organ Sharing database review. J Heart Lung Transplant. 2018;37(5):604–10 There are relatively few prospective data from large-scale studies of pre-transplant employment as a predictor of post-transplant outcomes This study’s findings show the need for future research in this area.

    Article  Google Scholar 

  37. • Rudasill SE, Iyengar A, Kwon OJ, Sanaiha Y, Dobaria V, Benharash P. Recipient working status in independently associated with outcomes in heart and lung transplantation. Clin Transpl. 2019;33:e13462. https://doi.org/10.1111/ctr.13462This study uses the same database as Ravi et al. although the time period used for data extraction varies slightly across studies. This study found that insurance status seemed to account in part for the association between work status and post-transplant survival. Both studies provide important data that should prompt additional studies.

    Article  Google Scholar 

  38. Casida JM, Combs P, Pavol M, Hickey KT. Ready, set, go: how patients and caregivers are prepared for self-management of an implantable ventricular assist device. ASAIO J. 2018;64(6):e151–5.

    Article  Google Scholar 

  39. Casida JM, Combs P, Schroeder SE, Hickey KT. Ventricular assist device self-management issues: the patient and caregiver perspectives. ASAIO J. 2018;64(6):e148–50.

    Article  Google Scholar 

  40. Bui QM, Allen LA, LeMond L, Brambatti M, Adler E. Psychosocial evaluation of candidates for heart transplant and ventricular assist devices: beyond the current consensus. Circ Heart Fail. 2019;12:e006058. https://doi.org/10.1161/CIRCHEARTFAILURE.119.006058.

    Article  PubMed  Google Scholar 

  41. Schneekloth TD, Hitschfeld MJ, Jowsey-Gregoire SG, Petterson TM, Dunlay SM, Niazi SK, et al. Psychosocial risk predicts new episode depression after heart transplant. Psychosomatics. 2019;60(1):47–55.

    Article  Google Scholar 

  42. Vandenbogaart E, Doering L, Chen B, Saltzman A, Chaker T, Creaser JW, et al. Evaluation of the SIPAT instrument to assess psychosocial risk in heart transplant candidates: a retrospective single center study. Heart Lung. 2017;46(4):273–9.

    Article  Google Scholar 

  43. Bui QM, Braun OO, Brambatti M, Gernhofer YK, Hernandez H, Pretorius V, et al. The value of Stanford integrated psychosocial assessment for transplantation (SIPAT) in prediction of clinical outcomes following left ventricular assist device (LVAD) implantation. Heart Lung. 2019;48(2):85–9.

    Article  Google Scholar 

  44. Halkar M, Nowacki AS, Kendall K, Efeovbokhan N, Gorodeski EZ, Moazami N, et al. Utility of the psychosocial assessment of candidates for transplantation in patients undergoing continuous-flow left ventricular assist device implantation. Prog Transplant. 2018;28(3):220–5.

    Article  Google Scholar 

  45. Cagliostro M, Bromley A, Ting P, Donehey J, Ferket B, Parks K, et al. Standardized use of the Stanford Integrated Psychosocial Assessment for Transplantation in LVAD patients. J Card Fail. 2019;25(9):735–43.

    Article  Google Scholar 

  46. Sperry BW, Ikram A, Alvarez PA, Perez AL, Kendall K, Gorodeski EZ, et al. Standardized psychosocial assessment before left ventricular assist device implantation: an important predictive measure. Circ Heart Fail. 2019;12:e005377. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005377.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mary Amanda Dew.

Ethics declarations

Conflict of Interest

Mary Amanda Dew’s effort in preparing this report was supported in part by grant R01 AG047416 from the National Institute on Aging, Rockville, MD. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Kathleen L. Grady has been a speaker for the American Heart Association and the Heart Failure Society of America. She and Annemarie Kaan are members of the Board of Directors, ISHLT. All of the authors were members of the leadership group of the 2018 consensus document [1••].

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Topical Collection on Nonpharmacologic Therapy: Surgery, Ventricular Assist Devices, Biventricular Pacing, and Exercise

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dew, M.A., DiMartini, A.F., Dobbels, F. et al. The Approach to the Psychosocial Evaluation of Cardiac Transplant and Mechanical Circulatory Support Candidates. Curr Heart Fail Rep 16, 201–211 (2019). https://doi.org/10.1007/s11897-019-00443-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11897-019-00443-0

Keywords

Navigation