Abstract
Background
Although the bioactive peptides associated with the apelinergic system are known to be associated with heart failure and ischemic heart disease, there are no data on their association with acromegaly.
Aim
We aimed to investigate the change in serum Elabela levels, a novel peptide of the apelinergic system, in patients with acromegaly.
Methods
Our study included 30 treatment naive patients who were recently diagnosed with acromegaly, and 50 age-and-sex-matched healthy controls. In addition to routine history, physical examination and laboratory examinations, serum Elabela level was measured. Participants were divided into two groups as individuals with and without acromegaly and compared to each other.
Results
Diastolic blood pressure (DBP) and systolic blood pressure (SBP) were found to be higher in patients with acromegaly. Serum glucose, Hs-CRP, NT-proBNP, insulin-like growth factor-1, growth hormone and serum Elabela levels were higher in patients with acromegaly (p < 0.05 for each). Left ventricular ejection fraction (LV-EF) was found to be lower in patients with acromegaly than the patients in healthy control group (p < 0.05). In multivariate analysis; age, systolic blood pressure, NT-proBNP, Insulin-like growth factor 1 and growth hormone levels were found to be very closely and positively related to serum Elabela level (p < 0.05 for each).
Conclusions
Serum Elabela level can be used as an early and objective indicator of early cardiovascular involvement in patients with acromegaly. Further research is needed to clarify the role of serum Elabela levels on cardiovascular system in acromegaly patients.
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Dr. Sumbul, Dr. Koc, Dr. Gulumsek, Dr. Ay and Dr. Avci Seyda: conceptualization, methodology, investigation, formal analysis, visualization, and writing – original draft. Dr. Sumbul, Dr. Gulumsek, Dr. Okyay and Dr. Sahin: conceptualization, methodology, resources, formal analysis, and writing – review and editing. Dr. Sumbul, Dr. Avci A, and Mr. Gold: conceptualization, methodology, and writing – review and editing. All authors read and approved the final version of the manuscript.
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The study was performed according to the recommendations set by the Declaration of Helsinki on Medical Research involving Human Subjects. The ethics committee of Cukurova University, Faculty of Medicine approved the study. Informed consent was obtained from all individual participants included in the study.
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The authors declare no competing interests.
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Sumbul, H.E., Gulumsek, E., Avci, B.S. et al. Serum Elabela level is significantly increased in patients with acromegaly. Ir J Med Sci 192, 665–670 (2023). https://doi.org/10.1007/s11845-022-03042-6
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DOI: https://doi.org/10.1007/s11845-022-03042-6