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Greater Short-Term Weight Loss in Women 20–45 versus 55–65 Years of Age Following Bariatric Surgery

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Abstract

Background

Whether and how sex and age affect bariatric-surgery outcome is poorly understood. Estrogens regulate body composition in women and animals, and increase weight loss in a rodent model of gastric bypass, suggesting that premenopausal women may lose more weight following bariatric surgery.

Methods

One thousand three hundred fifty-six female gastric-bypass or gastric-banding patients were retrospectively grouped as 20–45 years old (presumptively premenopausal; n = 1,199) and 55–65 years old (presumptively postmenopausal; n = 157). Mixed-model ANCOVA followed by Bonferroni-corrected t tests were used to categorically test the effect of age on percent excess body weight loss (%EBWL) at 1 and 2 years post-surgery, controlling for preoperative EBW and surgery type. Age effects were also tested dimensionally in all women and in 289 male patients.

Results

Twenty- to forty-five-year-old women showed greater %EBWL 1 and 2 years post-surgery than 55–65-year-old women (p’s < 0.0005). No age effect was detected in 20–25- vs. 30–35-, 30–35- vs. 40–45-, or 20–25- vs. 40–45-year-old women (p’s > 0.2) This age effect was detected only after gastric banding, with 20–45-year-old women losing ∼7 kg more than 55–65-year-old women after 2 years. Dimensional analysis confirmed a significant inverse effect of age on bariatric surgery outcome in women, but did not detect any effect in men.

Conclusions

Results indicate that 55–65-year-old women lose less weight than 20–45-year-old women in the initial 2 years after bariatric surgery, especially gastric banding; this may be mediated by age- or menopause-associated changes in physical activity, energy expenditure, or energy intake.

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Conflict of Interest Disclosures

Christopher Ochner, PhD: no conflict of interest

Julio Teixeira, MD: no conflict of interest

Nori Geary, PhD: no conflict of interest

Lori Asarian, PhD: no conflict of interest

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Authors and Affiliations

  1. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA

    Christopher N. Ochner

  2. New York Obesity Nutrition Research Center, St. Luke’s-Roosevelt Hospital Center, New York, NY, USA

    Christopher N. Ochner

  3. Center for Weight Loss Surgery, Department of Minimally Invasive Surgery, St. Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY, USA

    Julio Teixeira

  4. Zielackerstrasse 10, Schwerzenbach, Switzerland

    Nori Geary

  5. Institute of Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland

    Lori Asarian

  6. NY Obesity Research Center, St. Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue, Babcock 1020, New York, NY, 10025, USA

    Christopher N. Ochner

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  1. Christopher N. Ochner
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  2. Julio Teixeira
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Correspondence to Christopher N. Ochner.

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Ochner, C.N., Teixeira, J., Geary, N. et al. Greater Short-Term Weight Loss in Women 20–45 versus 55–65 Years of Age Following Bariatric Surgery. OBES SURG 23, 1650–1654 (2013). https://doi.org/10.1007/s11695-013-0984-1

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