Résumé
L’obésité est classiquement définie à partir de seuils d’indice de masse corporels associés à une augmentation de la morbidité et de la mortalité. Cette approche est pertinente en termes d’analyse populationnelle mais elle connaît des limites au niveau individuel. Les progrès en épidémiologie, physiopathologie et clinique de l’obésité doivent orienter vers de nouveaux phénotypes et de nouvelles nosographies d’obésités, à inclure dans un cadre plus général, celui des maladies du tissu adipeux.
Abstract
The definition of obesity is based on thresholds of body mass index associated with an increase in morbimortality. This approach is relevant at a population level but it reaches some limits as far as the individual is concerned. Advances in epidemiology, physiopathology and clinics of obesity should lead to new phenotypes and nosography of obesity included in a general framework of adipose tissue disorders
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Références
Bray GA (1990) Obesity: historical development of scientific and cultural ideas. Int J Obes 14:909–926
Weigley ES (2000). Adolphe Quetelet. Am J Clin Nutr 71:853
Faerstein E, Winkelstein W Jr (2012) Adolphe quetelet: statistician and more. Epidemiology 23:762–763
Stavig GR, Leonard AR, Igra A, Felten P (1984) Indices of relative body weight and ideal weight charts. J Chronic Dis 37:255–262
WHO World Health Organization (1998) Obesity: preventing and managing the global epidemic. Report of a WHO Consultation on Obesity. Geneva, 1997 (WHO/NUT/NCD/98.1)
Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report. National Institutes of Health (1998) Obes Res 6Suppl 2:S51–209
Basdevant A, Bouillot JL, Clément K, et al (eds) (2011) Traité de Médecine et Chirurgie de l’obésité. Médecine Sciences Ed Lavoisier Paris
Thibault R, Genton L, Pichard C (2012) Body composition: why, when and for who? Clin Nutr 31:435–447
Browning LM, Mugridge O, Dixon AK, et al (2011) Measuring abdominal adipose tissue: comparison of simpler methods with MRI. Obes Facts 4:9–15
Prentice AM, Jebb SA (2001) Beyond body mass index. Obes Rev 2:141–147
Frühbeck G (2008) Overview of adipose tissue and its role in obesity and metabolic disorders. Methods Mol Biol 456:1–22
Barreira TV, Harrington DM, Staiano AE, et al (2011) Body adiposity index, body mass index, and body fat in white and black adults. JAMA 306:828–830
Shah NR, Braverman ER (2012) Measuring Adiposity in Patients: The Utility of Body Mass Index (BMI), Percent Body Fat, and Leptin. PLoS One 7(4)
Müller MJ, Lagerpusch M, Enderle J, et al (2012) Beyond the body mass index: tracking body composition in the pathogenesis of obesity and the metabolic syndrome. Obes Rev 13Suppl 2:6–13
Gómez-Ambrosi J, Silva C, Catalán V, et al (2012) Clinical usefulness of a new equation for estimating body fat. Diabetes Care 35:383–388
Gómez-Ambrosi J, Silva C, Galofré JC, et al (2011) Body adiposity and type 2diabetes: increased risk with a high body fat percentage even having a normal BMI. Obesity (Silver Spring) 19:1439–1444
Frühbeck G, Toplak H, Woodward E, et al (2013) Obesity: The Gateway to Ill Health — an EASO Position Statement on a Rising Public Health
Després JP (2012) What is “metabolically healthy obesity”? From epidemiology to pathophysiological insights. J Clin Endocrinol Metab 97:2283–2285
Lavie CJ, De Schutter A, Milani RV (2013) Is there an obesity, overweight, or lean paradox in coronary heart disease? Getting to the ‘fat’ of the matter. Heart 7. [Epub ahead of print]
Tseng CH (2013) Obesity paradox: differential effects on cancer and noncancer mortality in patients with type 2 diabetes mellitus. Atherosclerosis 226:186–192
Florez H, Castillo-Florez S (2012) Beyond the obesity paradox in diabetes: fitness, fatness, and mortality. JAMA 8;308:619–620
Chrysant SG, Chrysant GS (2013) New insights into the true nature of the obesityparadox and the lower cardiovascular risk. J Am Soc Hypertens 7:85–94
Dixon JB, Lambert GW (2013) The obesity paradox—a reality that requires explanation and clinical interpretation. Atherosclerosis 226:47–48
Gielen S, Sandri M (2013) The obesity paradox — a scientific artifact? Int J Cardiol 162:140–142
Ferreira I, Stehouwer CD (2012) Obesity paradox or inappropriate study designs? Time for life-course epidemiology. J Hypertens 30:2271–2275
Flegal KM, Kit BK, Orpana H, Graubard BI (2013) Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and metaanalysis. JAMA 309:71–82
Flegal KM, Ogden CL (2011). Childhood obesity: are we all speaking the same language? Adv Nutr 2:159S–166S
Vague J (1956) The degree of masculine diffentiation of obesities: a risk factor determining predisposition to diabetes, atherosclerosis, gout and uric acid. Am J Clin Nutr 4:20–34
Vague J (1996) Sexual differentiation. A determinant factor of the forms of obesity. 1947. Obes Res 4:201–203
Capeau J, Magré J, Caron-Debarle M, et al (2010) Human lipodystrophies: genetic and acquired diseases of adipose tissue. Endocr Dev 19:1–20
Veilleux A, Caron-Jobin M, Noël S, et al (2011) Visceral adipocyte hypertrophy is associated with dyslipidemia independent of body composition and fat distribution in women. Diabetes 60:1504–1511
Arner P (2010) Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 59:105–109
Rydén M (2013) Variations in the Size of the Major Omentum Are Primarily Determined by Fat Cell Number. J Clin Endocrinol Metab. Mar 29. [Epub ahead of print]
Frayn K, Bernard S, Spalding K, Arner P (2012) Adipocyte triglyceride turnover is independently associated with atherogenic dyslipidemia. J Am Heart Assoc Dec 1(6):e003467. doi: 10.1161/JAHA.112.003467
Langin D (2011) In and out: adipose tissue lipid turnover in obesity and dyslipidemia. Cell Metab 14:569–570
Tordjman J, Divoux A, Prifti E, et al (2012) Structural and inflammatory heterogeneity in subcutaneous adipose tissue: relation with liver histopathology in morbid obesity. J Hepatol 56:1152–1158
Divoux A, Tordjman J, Lacasa D, et al (2010) Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss. Diabetes 59:2817–2825
Ippoliti F, Canitano N, Businaro R (2013) Stress and obesity as risk factors in cardiovascular diseases: a neuroimmune perspective. J Neuroimmune Pharmacol 8:212–226
Langin D (2010) Recruitment of brown fat and conversion of white into brown adipocytes: strategies to fight the metabolic complications of obesity? Biochim Biophys Acta 1801:372–376
Márquez-Quiñones A, Mutch DM, Debard C, et al (2010) DiOGenes Project. Adipose tissue transcriptome reflects variations between subjects with continued weight loss and subjects regaining weight 6 mo after caloric restriction independent of energy intake. Am J Clin Nutr 92:975–984
Bastard JP, Fève B (2012) The secretory face of the adipose cell: a tribute to two queens, leptin and adiponectin. Biochimie 94:2063–2064
Mattu HS, Randeva HS (2013) Role of adipokines in cardiovascular disease. J Endocrinol 216:T1–T36
Trayhurn P (2013) Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev 93:1–21
Aron-Wisnewsky J, Minville C, Tordjman J, et al (2012) Chronic intermittent hypoxia is a major triggerfor non-alcoholic fatty liver disease in morbid obese. J Hepatol 56:225–233
La Merrill M, Emond C, Kim MJ, et al (2013) Toxicological function of adipose tissue: focus on persistent organic pollutants. Environ Health Perspect 121:162–169
Clément K, Basdevant A, Dutour A (2009) Weight of pericardial fat on coronaropathy. Arterioscler Thromb Vasc Biol 29:615–616
Venteclef N, Guglielmi V, Balse E, et al (2013) Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion ofadipo-fibrokines. Eur Heart J Mar 22. [Epub ahead of print]
Chaix B, Bean K, Daniel M, et al (2012) Associations of supermarket characteristics with weight status and body fat: a multilevel analysis of individuals within supermarkets (RECORD study). PLoS One. 7(4):e32908
Oppert JM, Charreire H (2012) The importance of the food and physical activity environments. Nestle Nutr Inst Workshop Ser 73:113–121
Padwal RS, Pajewski NM, Allison DB, Sharma AM (2011) Using the Edmonton obesity staging system to predict mortality in a population-representative cohort of people with overweight and obesity. CMAJ 183:E1059–E1066
Frühbeck G (2012) Obesity: Screening for the evident in obesity. Nat Rev Endocrinol 8:570–572
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Basdevant, A., Clément, K. & Oppert, J.M. Vers de nouveaux phénotypes et de nouvelles nosographies : de l’obésité aux maladies du tissu adipeux. Obes 8, 234–243 (2013). https://doi.org/10.1007/s11690-013-0392-7
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DOI: https://doi.org/10.1007/s11690-013-0392-7