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Bio-corrosion and Cytotoxicity Studies on Novel Zr55Co30Ti15 and Cu60Zr20Ti20 Metallic Glasses

  • Symposium: Bulk Metallic Glasses XI
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Abstract

Metallic glasses are a potential and compatible implant candidate for biomedical applications. In the present investigation, a comparative study between novel Zr55Co30Ti15 and Cu60Zr20Ti20 metallic glasses is carried out to evaluate in vitro biocompatibility using simulated body fluids. The bio-corrosion behavior of Zr- and Cu-based metallic glasses in different types of artificial body fluids such as artificial saliva solution, phosphate-buffered saline solution, artificial blood plasma solution, and Hank’s balanced saline solution is evaluated using potentiodynamic polarization studies at a constant body temperature of 310.15 K (37 °C). Surface morphology of samples after bio-corrosion experiments was observed by scanning electron microscopy. In vitro cytotoxicity test on glassy alloys were performed using human osteosarcoma cell line as per 10993-5 guidelines from International Organization for Standardization. The comparative study between Zr- and Cu-based glassy alloys provides vital information about the effect of elemental composition on biocompatibility of metallic glasses.

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Acknowledgments

One of the authors, Jatin Bhatt, is thankful to INDO US Science and Technology forum for Fellowship award (IUSSTF Fellowship/16-2012) to carry out part of above research work at the Ames Laboratory (US-DOE), Iowa State University. This work was supported by the U.S. Department of Energy (DOE), Office of Basic Energy Science, Division of Materials Science and Engineering. The research was performed at the Ames Laboratory, which is operated for the U.S. DOE by Iowa State University under contract DE-AC02-07CH11358. The authors’ are also thankful to Technical Education Quality Improvement Program (TEQIP II), Government of India for providing financial assistance.

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Authors and Affiliations

  1. Department of Metallurgical and Materials Engineering, Visvesvaraya National Institute of Technology, Nagpur, 440010, India

    S. Vincent (Doctoral Student) & Jatin Bhatt (Associate Professor)

  2. Environmental Health Division, National Environmental Engineering Research Institute, Nagpur, 440020, India

    A. Daiwile (Doctoral Student) & S. S. Devi (Principal Scientist)

  3. Ames Laboratory, US Department of Energy, Iowa State University, Ames, IA, 50011, USA

    M. J. Kramer (Division Director) & M. F. Besser (Assistant Scientist)

  4. Department of Metallurgical and Materials Engineering, Indian Institute of Technology Madras, Chennai, 600036, India

    B. S. Murty (Professor)

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  1. S. Vincent
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  2. A. Daiwile
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Correspondence to Jatin Bhatt.

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Manuscript submitted July 28, 2014.

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Vincent, S., Daiwile, A., Devi, S.S. et al. Bio-corrosion and Cytotoxicity Studies on Novel Zr55Co30Ti15 and Cu60Zr20Ti20 Metallic Glasses. Metall Mater Trans A 46, 2422–2430 (2015). https://doi.org/10.1007/s11661-014-2574-9

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