Abstract
Background
Stapled pancreatic transection is widely used although pancreatic fistula remains a common post-surgical complication.
Methods
We performed a meta-analysis of existing data regarding pancreatic fistula following stapled pancreatic transection, comparing bare metal staples to reinforced staple loads.
Results
We identified ten manuscripts between 2007 and 2009 reporting outcomes following stapled division of the pancreas (five retrospective reviews, five prospective case series). A total of 483 stapled pancreatic resections are included in this meta-analysis. Of these, 234(48 %) were reinforced (REINF) and 249 (52 %) were bare staples (STPL). Out of 483 cases, there were a total of 100 documented pancreatic leaks (21 %). Sixty-one leaks were reported out of 249 STPL divisions (24 %), while 39 leaks were reported following REINF division (17 %). The overall relative risk of develo** a pancreatic fistula following distal pancreatectomy was not significantly different comparing STPL to REINF when all studies were combined (RR 1.00, 95% CI 0.65–1.53). We further evaluated the data stratifying by study design (prospective or retrospective) and found that prospective studies reported a significantly higher risk of pancreatic fistula with STPL compared to REINF technique (RR 14.45, 95 % CI 3.15–66.21).
Conclusion
Reinforced staples may be a preferred method of pancreatic stump closure following distal pancreatectomy.
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Disclosures
This study was performed with support from Covidien.
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This data will be presented in poster format at the upcoming DDW meeting in San Diego, CA May 2012
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Jensen, E.H., Portschy, P.R., Chowaniec, J. et al. Meta-analysis of Bioabsorbable Staple Line Reinforcement and Risk of Fistula Following Pancreatic Resection. J Gastrointest Surg 17, 267–272 (2013). https://doi.org/10.1007/s11605-012-2016-1
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DOI: https://doi.org/10.1007/s11605-012-2016-1