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Uterine endometrial carcinoma with DNA mismatch repair deficiency: magnetic resonance imaging findings and clinical features

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Abstract

Purpose

The purpose of this study was to identify the magnetic resonance imaging (MRI) features of uterine endometrial carcinoma (EC) with DNA mismatch repair (MMR) deficiency.

Materials and methods

This was a retrospective study approved by our institutional review board. The study included 118 patients pathologically diagnosed as having EC in our institution from April 2014 to December 2016. Of 118 patients, 8 were excluded because of insufficient data. Immunohistochemical analysis of MMR was performed retrospectively to observe the expressions of MLH1, MSH2, MSH6, and PMS2. A tumor with MMR deficiency was detected in 17 of 110 cases (15%). Clinical background characteristics and MRI findings were reviewed. These findings were compared between MMR deficiency group and the other group as a control group. Statistical significance was determined using the Fisher’s exact test and the Mann–Whitney U test, as appropriate.

Results

The clinical background characteristics of patients with EC with MMR deficiency were not significantly different from those of other patients. On MRI, the tumor was significantly more often located in the lower uterine site (MMR(−) vs. MMR(+): 29.4 vs. 8.9% [p = 0.0366]).

Conclusion

EC with MMR deficiency tends to be located lower in the uterus, though most other findings were not significantly different from those of EC without MMR deficiency.

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Abbreviations

MMR:

Mismatch repair

MSI:

Microsatellite instability

ADC:

Apparent diffusion coefficient

CRC:

Colorectal cancer

DWI:

Diffusion-weighted imaging

IHC:

Immunohistochemistry

MRI:

Magnetic resonance imaging

TMA:

Tissue microarray

EC:

Endometrial carcinoma

T1WI:

T1-weighted imaging

T2WI:

T2-weighted imaging

CE-T1WI:

Contrast-enhanced T1-weighted imaging

PTE:

Peritumoral enhancement

SEE:

Subendometrial enhancement

LUS:

Lower uterine segment

MSI:

Microsatellite instability

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Author information

Authors and Affiliations

  1. Department of Radiology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan

    Kiyoyuki Minamiguchi, Junko Takahama, Ryosuke Taiji, Natsuhiko Saito, Hiroshi Okada, Nagaaki Marugami, Toshiko Hirai & Kimihiko Kichikawa

  2. Department of Diagnostic Pathology, Nara Medical University, Kashihara, Nara, 634-8522, Japan

    Tomoko Uchiyama & Chiho Ohbayashi

  3. Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Nara, 634-8522, Japan

    Yasuhito Tanase, Ryuji Kawaguchi & Hiroshi Kobayashi

Authors
  1. Kiyoyuki Minamiguchi
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  2. Junko Takahama
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Corresponding author

Correspondence to Kiyoyuki Minamiguchi.

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Conflict of interest

Kiyoyuki Minamiguchi declares that he has no conflict of interest. Junko Takahama declares that she has no conflict of interest. Tomoko Uchiyama declares that she has no conflict of interest. Ryosuke Taiji declares that he has no conflict of interest. Natsuhiko Saito declares that he has no conflict of interest. Hiroshi Okada declares that he has no conflict of interest. Nagaaki Marugami declares that he has no conflict of interest. Yasuhito Tanase declares that he has no conflict of interest. Ryuji Kawaguchi declares that he has no conflict of interest. Chiho Ohbayashi declares that she has no conflict of interest. Hiroshi Kobayashi declares that he has no conflict of interest. Toshiko Hirai declares that she has no conflict of interest. Kimihiko Kichikawa declares that he has no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Minamiguchi, K., Takahama, J., Uchiyama, T. et al. Uterine endometrial carcinoma with DNA mismatch repair deficiency: magnetic resonance imaging findings and clinical features. Jpn J Radiol 36, 429–436 (2018). https://doi.org/10.1007/s11604-018-0741-4

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  • DOI: https://doi.org/10.1007/s11604-018-0741-4

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