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Association of Interleukin-6 -174G/C Polymorphism with the Risk of Diabetic Nephropathy in Type 2 Diabetes: A Meta-analysis

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Previous studies reported the association between interleukin-6 (IL-6) -174G/C gene polymorphism and the risk of diabetic nephropathy in type 2 diabetes mellitus (T2DN). However, the results remain controversial. In the present study, we conducted a meta-analysis to further examine this relationship between IL-6-174G/C gene polymorphism and T2DN. Three databases (PubMed, SinoMed and ISI Web of Science) were used to search clinical case-control studies about IL-6-174G/C polymorphism and T2DN published until Apr. 14, 2018. Fixed- or random-effects models were used to calculate the effect sizes of odds ratio (OR) and 95% confidence intervals (95% CI). Moreover, subgroup analysis was performed in terms of the excretion rate of albuminuria. All the statistical analyses were conducted using Stata 12.0. A total of 11 case-control studies were included in this study, involving 1203 cases of T2DN and 1571 cases of T2DM without DN. Meta-analysis showed that there was an association between IL-6-174G/C polymorphism and increased risk of T2DN under the allelic and recessive genetic models (G vs. C: OR=1.10, 95%CI 1.03–1.18, P=0.006; GG vs. CC+GC: OR=1.11, 95%CI 1.02–1.21 P=0.016). In the subgroup analysis by albuminuria, a significant association of IL-6-174G/C polymorphism with risk of T2DN was noted in the microalbuminuria group under the recessive model (OR=1.54, 95% CI 1.02–2.32, _P=0.038). In conclusion, this meta-analysis suggests that IL-6-174G/C gene polymorphism is associated with the risk of T2DN.

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Author notes

  1. Both authors contributed equally to this work.

Authors and Affiliations

  1. Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Zhen-hai Cui, Kang-li **ao, Yang Chen & Hui-qing Li

  2. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    **ao-ting Lu

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  1. Zhen-hai Cui
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  2. **ao-ting Lu
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  3. Kang-li **ao
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  4. Yang Chen
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  5. Hui-qing Li
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Corresponding author

Correspondence to Hui-qing Li.

Additional information

This study was supported by a grant from the Health Commission of Hubei Province of China (No. WJ2017M104).

Conflict of Interest Statement

The authors declare no competing financial interests in this study.

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Cui, Zh., Lu, Xt., **ao, Kl. et al. Association of Interleukin-6 -174G/C Polymorphism with the Risk of Diabetic Nephropathy in Type 2 Diabetes: A Meta-analysis. CURR MED SCI 39, 250–258 (2019). https://doi.org/10.1007/s11596-019-2027-1

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  • DOI: https://doi.org/10.1007/s11596-019-2027-1

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