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Crosstalk between trace elements and T-cell immunity during early-life health in pigs

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Abstract

With gradual ban on the use of antibiotics, the deficiency and excessive use of trace elements in intestinal health is gaining attention. In mammals, trace elements are essential for the development of the immune system, specifically T-cell proliferation, and differentiation. However, there remain significant gaps in our understanding of the effects of certain trace elements on T-cell immune phenotypes and functions in pigs. In this review, we summarize the specificity, development, subpopulations, and responses to pathogens of porcine T cells and the effects of functional trace elements (e.g., iron, copper, zinc, and selenium) on intestinal T-cell immunity during early-life health in pigs. Furthermore, we discuss the current trends of research on the crosstalk mechanisms between trace elements and T-cell immunity. The present review expands our knowledge of the association between trace elements and T-cell immunity and provides an opportunity to utilize the metabolism of trace elements as a target to treat various diseases.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (32172755, 32130099), the National Key Research and Development Program of China (2021YFD1300401), Huxiang Young Talent Support Program (2020RC3052), Hunan Key Research and Development Plan (2022NK2023), Guangxi Key Research and Development Plan (GuikeAB22035039), China Agriculture Research System of MOF and MARA (CARS-35), Changchun Academy Science and Technology Innovation Cooperation Project (21SH19), Tian** Synthetic Biotechnology Innovation Capacity Improvement Project (TSBICIP-CXRC-038)

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  1. Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan international joint laboratory of Animal Intestinal Ecology and Health, College of Life Sciences, Hunan Normal University, Changsha, 410081, China

    Liuqin He & Jianzhong Li

  2. Department of Animal Science, University of Manitoba, Winnipeg, Manitoba, R3T2N2, Canada

    Shunshun ** & Chenbo Yang

  3. CAS Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha, 410125, China

    Liuqin He & Tiejun Li

  4. Heilongjiang Academy of Agricultural Sciences, Harbin, 150086, China

    **nmiao He, Heshu Chen, Yanzhong Feng & Di Liu

  5. Animal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Animal Science Academy, Chengdu, 610066, China

    Wenjie Tang

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**, S., He, L., Yang, C. et al. Crosstalk between trace elements and T-cell immunity during early-life health in pigs. Sci. China Life Sci. 66, 1994–2005 (2023). https://doi.org/10.1007/s11427-022-2339-0

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