Log in

D-ribose increases triglyceride via upregulation of DGAT in the liver

  • Letter to the Editor
  • Published:
Science China Life Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Adolph, T.E., Grander, C., Grabherr, F., and Tilg, H. (2017). Adipokines and non-alcoholic fatty liver disease: Multiple interactions. Int J Mol Sci 18, 1649.

    Article  CAS  PubMed Central  Google Scholar 

  • Basaranoglu, M., Basaranoglu, G., Sabuncu, T., and Sentürk, H. (2013). Fructose as a key player in the development of fatty liver disease. World J Gastroenterol 19, 1166.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Beshara, A., Cohen, E., Goldberg, E., Lilos, P., Garty, M., and Krause, I. (2016). Triglyceride levels and risk of type 2 diabetes mellitus: A longitudinal large study. J Investig Med 64, 383–387.

    Article  PubMed  Google Scholar 

  • Chen, H.C., Smith, S.J., Ladha, Z., Jensen, D.R., Ferreira, L.D., Pulawa, L. K., McGuire, J.G., Pitas, R.E., Eckel, R.H., and Farese Jr., R.V. (2002). Increased insulin and leptin sensitivity in mice lacking acyl CoA: Diacylglycerol acyltransferase 1. J Clin Invest 109, 1049–1055.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen, X., Su, T., Chen, Y., He, Y., Liu, Y., Xu, Y., Wei, Y., Li, J., and He, R. (2017). D-Ribose as a contributor to glycated haemoglobin. Ebiomedicine 25, 143–153.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kawano, Y., and Cohen, D.E. (2013). Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. J Gastroenterol 48, 434–441.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kazumi, T., Kawaguchi, A., Hirano, T., and Yoshino, G. (2004). Serum adiponectin is associated with high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein particle size in young healthy men. Metabolism 53, 589–593.

    Article  CAS  PubMed  Google Scholar 

  • Sáinz, N., Barrenetxe, J., Moreno-Aliaga, M.J., and Martinez, J.A. (2015). Leptin resistance and diet-induced obesity: Central and peripheral actions of leptin. Metabolism 64, 35–46.

    Article  CAS  PubMed  Google Scholar 

  • Seghieri, M., Tricò, D., and Natali, A. (2017). The impact of triglycerides on glucose tolerance: Lipotoxicity revisited. Diabetes Metab 43, 314–322.

    Article  CAS  PubMed  Google Scholar 

  • Su T., and He R.Q. (2015) An insight of D-ribose metabolic imbalance in type 2 diabetes mellitus. Prog Biochem Biophys 42: 390–392.

    CAS  Google Scholar 

  • Su, T., **n, L., He, Y.G., Wei, Y., Song, Y.X., Li, W.W., Wang, X.M., and He, R.Q. (2013). The abnormally high level of uric D-ribose for type-2 diabetics. Prog Biochem Biophys 40, 816–825.

    Google Scholar 

  • Yen, C.L.E., Stone, S.J., Koliwad, S., Harris, C., and Farese Jr., R.V. (2008). Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res 49, 2283–2301.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yin, K., and Tang, C.K. (2011). Inflammation, lipid metabolism dysfunction, and hypertension: Active research fields in atherosclerosis-related cardiovascular disease in China. Sci China Life Sci 54, 976–979.

    Article  PubMed  Google Scholar 

  • Youngwanichsetha, S. (2018). Fatty liver: Risk factors and prevention. J Nutr Food Sci 8, e145.

    Google Scholar 

  • Yu, J., and Li, P. (2017). The size matters: Regulation of lipid storage by lipid droplet dynamics. Sci China Life Sci 60, 46–56.

    Article  CAS  PubMed  Google Scholar 

  • Zhou, Y., Wang, X., Fan, S., and He, R. (2018). A lumbrokinase isozyme targets hepatitis B e-antigen. Sci China Life Sci 61, 1596–1598.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Natural Science Foundation of China (31670805 and 81573763), the National Key Research and Development Program of China (2016YFC1305900 and 2016YFC1306300), the Bei**g Municipal Science and Technology Project (Z161100000217141 and Z161100000216137), the Youth Innovation Promotion Association CAS (2017132) and the National Basic Research Program (2012CB911004). We thank Chunhong Feng (the Affiliated Hospital of Southwest Medical University, Luzhou) for clinical sample collection, and **ang Shi andLei Zhou (Institute of Biophysics, CAS) for providing veterinary care, breeding, management of laboratory animals and technical support.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rongqiao He.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, Y., Yu, L., Wei, Y. et al. D-ribose increases triglyceride via upregulation of DGAT in the liver. Sci. China Life Sci. 62, 858–861 (2019). https://doi.org/10.1007/s11427-019-9542-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11427-019-9542-2

Navigation