References
Adolph, T.E., Grander, C., Grabherr, F., and Tilg, H. (2017). Adipokines and non-alcoholic fatty liver disease: Multiple interactions. Int J Mol Sci 18, 1649.
Basaranoglu, M., Basaranoglu, G., Sabuncu, T., and Sentürk, H. (2013). Fructose as a key player in the development of fatty liver disease. World J Gastroenterol 19, 1166.
Beshara, A., Cohen, E., Goldberg, E., Lilos, P., Garty, M., and Krause, I. (2016). Triglyceride levels and risk of type 2 diabetes mellitus: A longitudinal large study. J Investig Med 64, 383–387.
Chen, H.C., Smith, S.J., Ladha, Z., Jensen, D.R., Ferreira, L.D., Pulawa, L. K., McGuire, J.G., Pitas, R.E., Eckel, R.H., and Farese Jr., R.V. (2002). Increased insulin and leptin sensitivity in mice lacking acyl CoA: Diacylglycerol acyltransferase 1. J Clin Invest 109, 1049–1055.
Chen, X., Su, T., Chen, Y., He, Y., Liu, Y., Xu, Y., Wei, Y., Li, J., and He, R. (2017). D-Ribose as a contributor to glycated haemoglobin. Ebiomedicine 25, 143–153.
Kawano, Y., and Cohen, D.E. (2013). Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. J Gastroenterol 48, 434–441.
Kazumi, T., Kawaguchi, A., Hirano, T., and Yoshino, G. (2004). Serum adiponectin is associated with high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein particle size in young healthy men. Metabolism 53, 589–593.
Sáinz, N., Barrenetxe, J., Moreno-Aliaga, M.J., and Martinez, J.A. (2015). Leptin resistance and diet-induced obesity: Central and peripheral actions of leptin. Metabolism 64, 35–46.
Seghieri, M., Tricò, D., and Natali, A. (2017). The impact of triglycerides on glucose tolerance: Lipotoxicity revisited. Diabetes Metab 43, 314–322.
Su T., and He R.Q. (2015) An insight of D-ribose metabolic imbalance in type 2 diabetes mellitus. Prog Biochem Biophys 42: 390–392.
Su, T., **n, L., He, Y.G., Wei, Y., Song, Y.X., Li, W.W., Wang, X.M., and He, R.Q. (2013). The abnormally high level of uric D-ribose for type-2 diabetics. Prog Biochem Biophys 40, 816–825.
Yen, C.L.E., Stone, S.J., Koliwad, S., Harris, C., and Farese Jr., R.V. (2008). Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res 49, 2283–2301.
Yin, K., and Tang, C.K. (2011). Inflammation, lipid metabolism dysfunction, and hypertension: Active research fields in atherosclerosis-related cardiovascular disease in China. Sci China Life Sci 54, 976–979.
Youngwanichsetha, S. (2018). Fatty liver: Risk factors and prevention. J Nutr Food Sci 8, e145.
Yu, J., and Li, P. (2017). The size matters: Regulation of lipid storage by lipid droplet dynamics. Sci China Life Sci 60, 46–56.
Zhou, Y., Wang, X., Fan, S., and He, R. (2018). A lumbrokinase isozyme targets hepatitis B e-antigen. Sci China Life Sci 61, 1596–1598.
Acknowledgements
This work was supported by the National Natural Science Foundation of China (31670805 and 81573763), the National Key Research and Development Program of China (2016YFC1305900 and 2016YFC1306300), the Bei**g Municipal Science and Technology Project (Z161100000217141 and Z161100000216137), the Youth Innovation Promotion Association CAS (2017132) and the National Basic Research Program (2012CB911004). We thank Chunhong Feng (the Affiliated Hospital of Southwest Medical University, Luzhou) for clinical sample collection, and **ang Shi andLei Zhou (Institute of Biophysics, CAS) for providing veterinary care, breeding, management of laboratory animals and technical support.
Author information
Authors and Affiliations
Corresponding author
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Chen, Y., Yu, L., Wei, Y. et al. D-ribose increases triglyceride via upregulation of DGAT in the liver. Sci. China Life Sci. 62, 858–861 (2019). https://doi.org/10.1007/s11427-019-9542-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11427-019-9542-2