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Intermittent fasting: from calories to time restriction

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Abstract

The global human population has recently experienced an increase in life expectancy with a mounting concern about the steady rise in the incidence of age-associated chronic diseases and socio-economic burden. Calorie restriction (CR), the reduction of energy intake without malnutrition, is a dietary manipulation that can increase health and longevity in most model organisms. However, the practice of CR in day-to-day life is a challenging long-term goal for human intervention. Recently, daily fasting length and periodicity have emerged as potential drivers behind CR’s beneficial health effects. Numerous strategies and eating patterns have been successfully developed to recapitulate many of CR’s benefits without its austerity. These novel feeding protocols range from shortened meal timing designed to interact with our circadian system (e.g., daily time-restricted feeding) to more extended fasting regimens known as intermittent fasting. Here, we provide a glimpse of the current status of knowledge on different strategies to reap the benefits of CR on metabolic health in murine models and in humans, without the rigor of continuous reduction in caloric intake as presented at the USU State of the Science Symposium.

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Funding

This study was supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health. L.C.D.P.W. was supported by the NIH Grant #Fi2GM123963 from the National Institute of General Medical Sciences of the National Institutes of Health.

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  1. Eleonora Duregon and Laura C.D. Pomatto-Watson contributed equally to this review article.

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  1. Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA

    Eleonora Duregon, Laura C.D. D. Pomatto-Watson, Michel Bernier, Nathan L. Price & Rafael de Cabo

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  1. Eleonora Duregon
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Correspondence to Rafael de Cabo.

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Duregon, E., Pomatto-Watson, L.C.D., Bernier, M. et al. Intermittent fasting: from calories to time restriction. GeroScience 43, 1083–1092 (2021). https://doi.org/10.1007/s11357-021-00335-z

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