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A better roadmap for designing novel bioactive glasses: effective approaches for the development of innovative revolutionary bioglasses for future biomedical applications

  • Advanced Nanobiomaterials for Environmental Remediation
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Abstract

The introduction of bioactive glasses (BGs) precipitated a paradigm shift in the medical industry and opened the path for the development of contemporary regenerative medicine driven by biomaterials. This composition can bond to live bone and can induce osteogenesis by the release of physiologically active ions. 45S5 BG products have been transplanted effectively into millions of patients around the world, primarily to repair bone and dental defects. Over the years, many other BG compositions have been introduced as innovative biomaterials for repairing soft tissue and delivering drugs. When research first started, many of the accomplishments that have been made today were unimaginable. It appears that the true capacity of BGs has not yet been realized. Because of this, research involving BGs is extremely fascinating. However, to be successful, it requires interdisciplinary cooperation between physicians, glass chemists, and bioengineers. The present paper gives a picture of the existing clinical uses of BGs and illustrates key difficulties deserving to be faced in the future. The challenges range from the potential for BGs to be used in a wide variety of applications. We have high hopes that this paper will be of use to both novice researchers, who are just beginning their journey into the world of BGs, as well as seasoned scientists, in that it will promote conversation regarding potential additional investigation and lead to the discovery of innovative medical applications for BGs.

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Funding

This study received financial support from the National Institute of Dental & Craniofacial Research of the National Institutes of Health for awards R15DE027533, R56 DE029191, and 3R15DE027533-01A1W1.

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Authors and Affiliations

  1. Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

    Ehsan Vafa, Milad Abbasi & Ali Mohamad Amani

  2. Marquette University School of Dentistry, Milwaukee, WI, USA

    Lobat Tayebi

  3. Department of Chemistry and Chemical Engineering, Islamic Azad University, Rasht, Rasht Branch, Iran

    Mohammad Javad Azizli

  4. Department of Materials Science and Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran

    Reza Bazargan-Lari

  5. Department of Civil Engineering, Jami Institute of Technology, Isfahan, Iran

    Amirreza Talaiekhozani

  6. Alavi Educational and Cultural Complex, Shiraz, Iran

    Amirreza Talaiekhozani

  7. Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Zahra Zareshahrabadi

  8. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

    Ahmad Vaez

  9. Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100, Kuala Lumpur, Malaysia

    Hesam Kamyab

  10. Department of Biomaterials, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai 600077, India, Chennai, India

    Hesam Kamyab

  11. Engineering Department, Razak Faculty of Technology & Informatics, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100, Kuala Lumpur, Malaysia

    Shreeshivadasan Chelliapan

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  1. Ehsan Vafa
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  7. Zahra Zareshahrabadi
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  8. Ahmad Vaez
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Contributions

The authors of this manuscript contributed to the study conception and design. Material preparation and data collection and analysis were performed by Ehsan Vafa, Lobat Tayebi, Amirreza Talaiekhozani, and Milad Abbasi. The first draft of the manuscript was written by Ahmad Vaez, Mohammad Javad Azizli, Lobat Tayebi, Reza Bazargan-Lari, and Hesam Kamyab. Other authors including Ali Mohammad Amani, Hesam Kamyab, and Shreeshivadasan Chelliapan commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Ahmad Vaez.

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Vafa, E., Tayebi, L., Abbasi, M. et al. A better roadmap for designing novel bioactive glasses: effective approaches for the development of innovative revolutionary bioglasses for future biomedical applications. Environ Sci Pollut Res 30, 116960–116983 (2023). https://doi.org/10.1007/s11356-022-24176-1

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