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Bovine papillomavirus type 7 in Italy: complete genomes and sequence variants

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Abstract

Two novel bovine papillomavirus type 7 (BPV-7) variants have been identified in teat cutaneous papillomas affecting dairy cows in northern Italy. The entire genome sequences of two BPV-7 Italian variants showed major sequence differences in the long control region (LCR) and in the L2 gene compared to the Japanese reference strain. In order to define the stability of these genetic variants, the L2 and LCR sequences of seven further BPV-7 positive isolates were characterized. An insertion of six amino acids in the L2 structural protein has been detected in all samples while different genetic variants have been identified for the LCR. These findings provide new insights on intra-type variability of BPVs and represent a starting point for future studies aimed at establishing the biological role of the different BPV genomic regions and investigating the pathogenic potential of papillomavirus variants.

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Author notes

    Authors and Affiliations

    1. Department of Veterinary Medical Sciences, Alma Mater Studiorum, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano Emilia, Bologna, Italy

      Federica Savini, Laura Gallina & Alessandra Scagliarini

    2. Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Via Vienna 2, 07100, Sassari, Italy

      Alberto Alberti

    3. Infections and Cancer Program, German Cancer Research Center (DKFZ), F035, Im Neuenheimer Feld 242, 69120, Heidelberg, Germany

      Martin Müller

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    1. Federica Savini
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    2. Laura Gallina
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    3. Alberto Alberti
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    4. Martin Müller
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    5. Alessandra Scagliarini
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    Correspondence to Laura Gallina.

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    Human and Animal Rights

    All the applicable international and national guidelines for the care and use of animals were followed while collecting the samples analysed in this study.

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    Edited by Keizo Tomonaga.

    Federica Savini and Laura Gallina equally contributed to the paper.

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    Savini, F., Gallina, L., Alberti, A. et al. Bovine papillomavirus type 7 in Italy: complete genomes and sequence variants. Virus Genes 52, 253–260 (2016). https://doi.org/10.1007/s11262-016-1298-x

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    • DOI: https://doi.org/10.1007/s11262-016-1298-x

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