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Chronic kidney disease progression in aged patients

  • Nephrology - Original Paper
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Abstract

Purpose

Chronic kidney disease (CKD) is a major morbidity, and its prevalence increases with age. However, there appears to be some confusion about the prognosis of CKD in aged patients, because, it has its own characteristics different from youngers. In this study, we investigated the progression of CKD and related factors in aged patients.

Methods

This was a retrospective study including 334 patients over 80 years of age that were diagnosed with stage 3–4 CKD at our CKD clinic. CKD progression was assessed as an annual decline in the estimated glomerular filtration rate (eGFR). Comorbidities were globally categorized with the Charlson comorbidity index (CCI), but diabetes mellitus, hypertension, and cardiac morbidities were evaluated separately. Patients were grouped as either ‘progression to end-stage renal disease (ESRD)’ or ‘others’.

Results

During the follow-up period, 191 (57.2%) patients exhibited progression; the annual median eGFR declined by 0.8 ml/min/1.73 m2. Only 27 (8.1%) of these patients progressed to ESRD. In univariant and multivariate models, respectively, progressing to ESRD was significantly associated with cardiac comorbidities (p < 0.001, p < 0.001), proteinuria (p < 0.001, p = 0.03), and the baseline eGFR value (p < 0.001, p < 0.001).

Conclusion

In aged patients, CKD progressed slowly, but particularly high initial creatinine levels and proteinuria could be indicator of progression. In addition, cardiac comorbidities may facilitate progression to ESRD.

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Data availability

Data are available on request from the authors.

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Authors and Affiliations

  1. Marmara University Pendik Training and Research Hospital, Fevzi Çakmak District, Muhsin Yazıcıoğlu Street No:10 Pendik, 34899, Istanbul, Turkey

    Murat Tuğcu & Dilek Barutçu Ataş

Authors
  1. Murat Tuğcu
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  2. Dilek Barutçu Ataş
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Contributions

M.T.: provided the conception and design of the study, acquisition of data, analysis and interpretation of data, drafting the article, revised it critically for important intellectual content, and final approval of the version to be submitted; and D.B.A.: provided the revised article critically for important intellectual content and gave final approval of the version to be submitted.

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Correspondence to Murat Tuğcu.

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Conflict of interest

All the authors have no conflict of interest to report.

Ethics approval

The study was reviewed and approved by the Ethics Advisory Committee of Marmara University Medical School (approval number: 04/09/2020-1011).

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Tuğcu, M., Barutçu Ataş, D. Chronic kidney disease progression in aged patients. Int Urol Nephrol 53, 2619–2625 (2021). https://doi.org/10.1007/s11255-021-02806-w

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  • DOI: https://doi.org/10.1007/s11255-021-02806-w

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