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Synthesis, structure, antioxidation and DNA-binding studies of a zinc(II) complex with tris(2-benzimidazylmethyl)amine and cinnamate

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Abstract

A ternary zinc(II) complex containing a tripodal ligand tris(2-benzimidazylmethyl)amine (ntb) and a cinnamate with composition [Zn(ntb)(cinnamate)]NO3·DMF was synthesized and characterized by physico-chemical and spectroscopic methods. Single-crystal X-ray diffraction revealed that the central zinc(II) atom is five-coordinated in a distorted trigonal-bipyramid geometry. The DNA-binding properties of the zinc(II) complex were investigated by spectrophotometric methods and viscosity measurements, and the results suggested that the zinc(II) complex bind to DNA via an intercalation binding mode. Additionally, zinc(II) complex exhibited potential scavenge hydroxyl radical properties in in vitro studies.

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Acknowledgments

The present research was supported by the National Natural Science Foundation of China (Grant No. 21367017), the Fundamental Research Funds for the Gansu Province Universities (212086), National Natural Science Foundation of Gansu Province (Grant No. 1212RJZA037), and ‘Qing Lan’ Talent Engineering Funds for Lanzhou Jiaotong University.

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  1. School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, 730070, People’s Republic of China

    **a Tang, Zaihui Yang, Jiawen Zhang, Chengyong Chen & Huilu Wu

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  2. Zaihui Yang
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Correspondence to Huilu Wu.

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Tang, X., Yang, Z., Zhang, J. et al. Synthesis, structure, antioxidation and DNA-binding studies of a zinc(II) complex with tris(2-benzimidazylmethyl)amine and cinnamate. Res Chem Intermed 41, 4349–4360 (2015). https://doi.org/10.1007/s11164-014-1534-8

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