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Molecular profiling in breast cancer

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Abstract

Molecular profiling has provided biological evidence for the heterogeneity of breast cancer through the identification of intrinsic subtypes like Luminal A, Luminal B, HER2+/ER− and basal-like. It has also led to the development of clinically applicable gene expression-based prognostic panels like the Mammaprint® and Oncotype Dx™. The increasingly sophisticated understanding allowed by this and similar technology promises future individualized therapy.

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  1. GlaxoSmithKline, Research Triangle Park, NC, USA

    Shannon R. Morris

  2. Division of Hematology and Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, 3009 Old Clinic Building, CB # 7305, Chapel Hill, NC, 27599-7305, USA

    Shannon R. Morris & Lisa A. Carey

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Morris, S.R., Carey, L.A. Molecular profiling in breast cancer. Rev Endocr Metab Disord 8, 185–198 (2007). https://doi.org/10.1007/s11154-007-9035-3

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