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A comprehensive catalogue of EQ-5D scores in chronic disease: results of a systematic review

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Abstract

Purpose

Chronic diseases are associated with impaired health-related quality of life (HRQoL) outcomes. Comparison of HRQoL outcomes between different diseases and with the general population is of major importance to health economists, epidemiologists, clinicians, and policy makers. The aim of this systematic literature review was to develop a catalogue with EQ-5D scores in chronic non-communicable diseases, and to compare these scores with reference values from the general population.

Methods

MEDLINE, Embase, and Web of Science were systematically searched independently by two reviewers. Studies were included if they reported mean EQ-5D index values for the adult population and if these scores were compared with the general population. The QualSyst tool for quantitative research was used for quality appraisal.

Results

Two hundred and seven articles met the inclusion criteria. An extensive catalogue summarizes the EQ-5D scores in a wide variety of chronic diseases. Mean EQ-5D index values ranged between − 0.20 and 1. Lower EQ-5D scores are reported in chronic diseases compared to the general population, specifically in neurological disorders. Most of the diseases demonstrate a substantial disutility, although a minority of diseases have equal or even higher index scores than the general population.

Conclusion

A comprehensive, international catalogue has been developed to provide EQ-5D index scores for diverse chronic diseases compared with reference values based on the available literature. The catalogue gives a clear overview of the existing EQ-5D scores and can be rapidly accessed by researchers worldwide for different applications such as health economic evaluations, decision making, resource allocation, and other policy objectives. Future studies should focus on unexamined diseases and specific patient groups to expand the evidence base on HRQoL in chronic diseases.

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Funding

This study was funded by a Grant from Ghent University (Grant No. 01N02618) (Bijzonder Onderzoeksfonds, BOF).

Author information

Authors and Affiliations

  1. Department of Public Health and Primary Care, University Hospital, Ghent University, Ghent, Belgium

    Lisa Van Wilder, Els Clays & Delphine De Smedt

  2. Department of Radiation Oncology and Experimental Cancer Research, Ghent University, Ghent, Belgium

    Elke Rammant

  3. Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium

    Brecht Devleesschauwer

  4. Department of Veterinary Public Health and Food Safety, Ghent University, Merelbeke, Belgium

    Brecht Devleesschauwer

  5. The Knowledge Center for Health Ghent, Ghent University, Ghent, Belgium

    Nele Pauwels

Authors
  1. Lisa Van Wilder
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Correspondence to Lisa Van Wilder.

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Van Wilder, L., Rammant, E., Clays, E. et al. A comprehensive catalogue of EQ-5D scores in chronic disease: results of a systematic review. Qual Life Res 28, 3153–3161 (2019). https://doi.org/10.1007/s11136-019-02300-y

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