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Predictive role of dynamic contrast enhanced T1-weighted MR sequences in pre-surgical evaluation of macroadenomas consistency

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An Erratum to this article was published on 21 November 2016

Abstract

Purpose

Our hypothesis was that pituitary macroadenomas show different areas of consistency detectable by enhanced magnetic resonance imaging (MRI) with Dynamic study during gadolinium administration.

Materials and methods

We analysed 21 patients with pituitary macroadenomas between June 2013 and June 2015. All patients underwent trans-sphenoidal surgery and neurosurgeon described macroadenomas consistency. Similarly, two neuroradiologists manually drew regions of interest (ROIs) inside the solid-appearing portions of macroadenoma and in the normal white matter both on dynamic and post-contrast acquisitions. The ratio between these ROIs, defined as Signal Intensity Ratio (SIR), allowed obtaining signal intensity curves over time on dynamic acquisition and a single value on post-contrast MRI. SIR values best differentiating solid from soft macroadenoma components were calculated and correlated with pathologic patterns. A two-sample T test and empiric receiver operating characteristic (ROC) curve of SIR was performed.

Results

According to ROC analysis, the SIR value of 1.92, obtained by dynamic acquisition, best distinguished soft and hard components. All the specimens from soft components were characterized by high cellularity, high representation of vascularization and micro-haemorrhage and low percentage of collagen content. The reverse was evident in hard components.

Conclusions

We demonstrated that dynamic MRI acquisition could distinguish with good accuracy macroadenomas consistency.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Neuroradiology, S. Andrea Hospital, University Sapienza, Rome, Italy

    Andrea Romano, Maria Camilla Rossi Espagnet, Francesca Tavanti & Alessandro Bozzao

  2. Department of Odontostomatological and Maxillo-Facial Sciences, Umberto I Hospital, University Sapienza, Rome, Italy

    Andrea Romano

  3. Department of Histopathology, S. Andrea Hospital, University Sapienza, Rome, Italy

    Mariangela Lombardi & Domenica Di Stefano

  4. Department of Neurosurgery, S. Andrea Hospital, University Sapienza, Rome, Italy

    Luigi Lavorato, Emanuela Caroli & Giuseppe Trillò

  5. Department of Neuroradiology, S. Carlo Hospital, Potenza, Italy

    Valeria Coppola

  6. Department of Radiotherapy, S. Andrea Hospital, University Sapienza, Rome, Italy

    Giuseppe Minniti

  7. Neuroradiology Unit, Imaging Department, Bambino Gesù Children’s Hospital, Rome, Italy

    Maria Camilla Rossi Espagnet

Authors
  1. Andrea Romano
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  2. Valeria Coppola
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  3. Mariangela Lombardi
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  4. Luigi Lavorato
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  5. Domenica Di Stefano
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  6. Emanuela Caroli
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  7. Maria Camilla Rossi Espagnet
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  8. Francesca Tavanti
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  9. Giuseppe Minniti
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  10. Giuseppe Trillò
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  11. Alessandro Bozzao
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Corresponding author

Correspondence to Andrea Romano.

Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s11102-016-0774-6.

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Romano, A., Coppola, V., Lombardi, M. et al. Predictive role of dynamic contrast enhanced T1-weighted MR sequences in pre-surgical evaluation of macroadenomas consistency. Pituitary 20, 201–209 (2017). https://doi.org/10.1007/s11102-016-0760-z

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  • DOI: https://doi.org/10.1007/s11102-016-0760-z

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