Abstract
The pituicytoma is an extremely rare and little-studied primary tumour of the adult neurohypophysis. With total resection, the pituicytoma appears to have a good prognosis. However, its highly vascular nature makes total resection difficult and local recurrence after subtotal resection is not uncommon. To date, only 40 cases of pituicytoma have been reported in literature. In addition to our own case of a suprasellar pituicytoma, we are reviewing and discussing these with particular attention paid on the surgical management and outcome of this rare neoplasm.
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References
Saeger W (2010) Bericht über das Hypophysenregister im Jahre 2009 der Arbeitsgemeinschaft Hypophyse und Hypophysentumore der DGE. Endokrinologie Informationen 34(3):59–67
Brat DJ, Scheithauer BW, Fuller GN, Tihan T (2007) Newly codified glial neoplasms of the 2007 WHO classification of tumors of the central nervous system: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma. Brain Pathol 17:319–324
Louis DN, Ohgaki H, Wiestler OH, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classiwcation of tumours of the central nervous system. Acta Neuropathol 114:97–109
Furtado SV, Ghosal N, Venkatesh PK, Gupta K, Hegde AS (2010) Diagnostic and clinical implications of pituicytoma. J Clin Neurosci 17:938–943
Nakasu Y, Nakasu S, Saito A, Horiguchi S, Kameya T (2006) Pituicytoma. Two case reports. Neurol Med Chir (Tokyo) 46,152–156
Wolfe SQ, Bruce J, Morcos JJ (2008) Pituicytoma: case report. Neurosurgery 63:E173–E174
Brat DJ, Scheithauer BW, Staugaitis SM, Holtzman RN, Morgello S, Burger PC (2000) Pituicytoma: a distinctive low-grade glioma of the neurohypophysis. Am J Surg Pathol 24:362–368
Takei Y, Seyama S, Pearl GS, Tindall GT (1980) Ultrastructural study of the human neurohypophysisII. cellular elements of neural parenchyma, the pituicytes. Cell Tissue Res 205:273–287
Hatton GI (1988) Pituicytes, glia and control of terminal secretion. J Exp Biol 139:67–79
Cenacchi G, Giovenali P, Castrioto C, Giangaspero F (2001) Pituicytoma: ultrastructural evidence of a possible origin from folliculo-stellate cells of the adenohypophysis. Ultrastruct Pathol 25:309–312
Ulm AJ, Yachnis AT, Brat DJ, Rhoton AL Jr (2004) Pituicytoma: report of two cases and clues regarding histogenesis. Neurosurgery 54:753–758
Hurley TR, D’Angelo CM, Clasen RA, Wilkinson SB, Passavoy RD (1994) Magnetic resonance imaging and pathological analysis of a pituicytoma: case report. Neurosurgery 35:314–317
Schaller B, Kirsch E, Tolnay M, Mindermann T (1998) Symptomatic granular cell tumor of the pituitary gland: case report and review of the literature. Neurosurgery 42:166–171
Benveniste RJ, Purohit D, Byun H (2006) Pituicytoma presenting with spontaneous hemorrhage. Pituitary 9:53–58
Chen KT (2005) Crush cytology of pituicytoma. Diagn Cytopathol 33:255–257
Figarella-Branger D, Dufour H, Fernandez C, Bouvier-Labit C, Grisoli F, Pellissier JF (2002) Pituicytomas, a mis-diagnosed benign tumor of the neurohypophysis: Report of three cases. Acta Neuropathol 104:313–319
Gibbs WN, Monuki ES, Linskey ME, Hasso AN (2006) Pituicytoma: diagnostic features on selective carotid angiography and MR imaging. AJNR Am J Neuroradiol 27:1639–1642
Katsuta T, Inoue T, Nakagaki H, Takeshita M, Morimoto K, Iwaki T (2003) Distinctions between pituicytoma and ordinary pilocytic astrocytoma: case report. J Neurosurg 98:404–406
Kowalski RJ, Prayson RA, Mayberg MR (2004) Pituicytoma. Ann Diagn Pathol 8:290–294
Newnham HH, Rivera-Woll LM: Hypogonadism due to pituicytoma in an identical twin. N Engl J Med 359(26),2824 (2008)
Orrego JJ (2009) Pituicytoma and isolated ACTH deficiency. Pituitary 12:371–372
Phillips JJ, Misra A, Feuerstein BG, Kunwar S, Tihan T (2010) Pituicytoma: characterization of a unique neoplasm by histology, immunohistochemistry, ultrastructure, and array-based comparative genomic hybridization. Arch Pathol Lab Med 134:1063–1069
Schober R, Meixensberger J, Tannapfel A, Zimmer C, Wiestler OD (2004) Pituicytoma: a new brain tumor entity? Pathol Res Prac 200:333–337
Schultz AB, Brat DJ, Oyesiku NM, Hunter SB (2001) Intrasellar pituicytoma in a patient with other endocrine neoplasms. Arch Pathol Lab Med 125:527–530
Shah B, Lipper MH, Laws ER, Lopes MB, Spellman MJ Jr (2005) Posterior pituitary astrocytoma: arare tumor of the neurohypophysis: Acase report. AJNR Am J Neuroradiol 26:1858–1861
Takei H, Goodman JC, Tanaka S, Bhattacharjee MB, Bahrami A, Powell SZ (2005) Pituicytoma incidentally found at autopsy. Pathol Int 55:745–749
Thiryayi WA, Gnanalingham KK, Reid H, Heald A, Kearney T (2007) Pituicytoma: a misdiagnosed benign tumour of the posterior pituitary. Br J Neurosurg 21(1):47–48
Uesaka T, Miyazono M, Nishio S, Iwaki T (2002) Astrocytoma of the pituitary gland (pituicytoma): case report. Neuroradiology 44:123–125
Zhang F, Chen J, You C (2010) Pituicytoma: case report and review of the literature. Neurol India 58(5):799–801
Zhi L, Yang L, Quan H, Bai-ning L (2009) Pituicytoma presenting with atypical histological features. Pathology 41(5):505–508
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Pirayesh Islamian, A., Buslei, R., Saeger, W. et al. Pituicytoma: overview of treatment strategies and outcome. Pituitary 15, 227–236 (2012). https://doi.org/10.1007/s11102-011-0317-0
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DOI: https://doi.org/10.1007/s11102-011-0317-0