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Nano-Fibrous Tissue Engineering Scaffolds Capable of Growth Factor Delivery

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ABSTRACT

Tissue engineering aims at constructing biological substitutes to repair damaged tissues. Three-dimensional (3D) porous scaffolds are commonly utilized to define the 3D geometry of tissue engineering constructs and provide adequate pore space and surface to support cell attachment, migration, proliferation, differentiation and neo tissue genesis. Biomimetic 3D scaffolds provide synthetic microenvironments that mimic the natural regeneration microenvironments and promote tissue regeneration process. While nano-fibrous (NF) scaffolds are constructed to mimic the architecture of NF extracellular matrix, controlled-release growth factors are incorporated to modulate the regeneration process. The present article summarizes current advances in methods to fabricate NF polymer scaffolds and the technologies to incorporate controlled growth factor delivery systems into 3D scaffolds, followed by examples of accelerated regeneration when the scaffolds with growth factor releasing capacity are applied in animal models.

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Abbreviations

3D:

three-dimensional

BMP-7:

bone morphogenetic protein-7

ECM:

extra-cellular matrix

MS:

microspheres

NF:

nano-fibrous

NS:

nanospheres

PCL:

poly(ε-caprolactone)

PDGF:

platelet-derived growth factor

PEO:

poly(ethylene oxide)

PGA:

poly(glycolic acid)

PLA:

poly(lactic acid)

PLGA:

poly(lactic acid-co-glycolic acid)

PLLA:

poly(L-lactic acid)

SW:

solid-walled

TIPS:

thermally induced phase separation

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ACKNOWLEDGMENTS

The authors gratefully acknowledge the past and present grant support to our research in biologic delivery and biomimetic tissue engineering scaffolds from the NIH (DE014755, DE015384, GM075840, DE017689).

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Authors and Affiliations

  1. Department of Biologic and Materials Sciences, The University of Michigan, 1011 North University Ave., Room 2211, Ann Arbor, Michigan, 48109-1078, USA

    Jiang Hu & Peter X. Ma

  2. Department of Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan, 48109, USA

    Peter X. Ma

  3. Macromolecular Science and Engineering Center, The University of Michigan, Ann Arbor, Michigan, 48109, USA

    Peter X. Ma

  4. Department of Materials Science and Engineering, The University of Michigan, Ann Arbor, Michigan, 48109, USA

    Peter X. Ma

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Hu, J., Ma, P.X. Nano-Fibrous Tissue Engineering Scaffolds Capable of Growth Factor Delivery. Pharm Res 28, 1273–1281 (2011). https://doi.org/10.1007/s11095-011-0367-z

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