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Synthesis and biological activity of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo-and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and their reduction products

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Abstract

A series of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo-and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and products of their reduction has been synthesized and their pharmacological properties have been studied. Most of the synthesized substances possess weak antioxidant activity. At the same time, they exhibit pronounced antiaggregant and hemorheological properties, possess spasmolytic activity, and influence the blood glucose level.

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Authors and Affiliations

  1. Institute of Physical and Organic Chemistry, Rostov State University, Rostov-on-Don, Russia

    V. A. Anisimova

  2. Southern Scientific Center, Russian Academy of Sciences, Rostov-on-Don, Russia

    I. E. Tolpygin

  3. Volga Region Scientific Center, Russian Academy of Medical Sciences, Volgograd, Russia

    V. A. Kosolapov, A. V. Stepanov & A. F. Kucheryavenko

  4. Volgograd State Medical University, Volgograd, Russia

    A. A. Spasov

Authors
  1. V. A. Anisimova
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  2. I. E. Tolpygin
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  3. A. A. Spasov
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  4. V. A. Kosolapov
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  5. A. V. Stepanov
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  6. A. F. Kucheryavenko
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 5, pp. 27–33, May, 2006.

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Anisimova, V.A., Tolpygin, I.E., Spasov, A.A. et al. Synthesis and biological activity of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo-and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and their reduction products. Pharm Chem J 40, 261–267 (2006). https://doi.org/10.1007/s11094-006-0105-8

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  • DOI: https://doi.org/10.1007/s11094-006-0105-8

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