SpringerLink
Log in

The Anticonvulsant Screening Program of the National Institute of Neurological Disorders and Stroke, NIH: History and Contributions to Clinical Care in the Twentieth Century and Beyond

  • Original Paper
  • Published:
Neurochemical Research Aims and scope Submit manuscript

Abstract

The anticonvulsant screening program (ASP) of the national institute of neurological disorders and stroke (NINDS), National Institutes of Health has made substantial contributions to the drug armamentarium of the clinical neurologist. This program, originally a part of the overall Drug Development Program of the Epilepsy Branch, has been fortunate to have talented leadership, both at NINDS in Maryland and at the major contract site, the University of Utah–over a remarkable period of more than 40 years. Future discoveries by the ASP (now renamed the Epilepsy Therapy Screening) can be expected to make additional contributions to improving the health of persons with epilepsy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price includes VAT (Germany)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Choi D et al (2014) Medicines for the mind: policy-based “pull” incentives for creating breakthrough CNS drugs. Neuron 84:554–563

    Article  CAS  PubMed  Google Scholar 

  2. Putnam TJ, Merritt HH (1937) Experimental determination of the anticonvulsant properties of some phenyl derivatives. Science 85:525–526

    Article  CAS  PubMed  Google Scholar 

  3. Lennox WG (1945) The petit mal epilepsies. Their treatment with Tridione. JAMA 129:1069–1074

    Article  CAS  Google Scholar 

  4. Swinyard EA, Browne WC, Goodman LS (1952) Comparative assays of antiepileptic drugs in mice and rats. J Pharmacol Exp Ther 106:319–330

    CAS  PubMed  Google Scholar 

  5. PorterRJ, Kupferberg HJ, Hessie BJ (2015) Mechanisms of action of anti-seizure drugs and the anticonvulsant screening program of the National Institute of Neurological Disorders and Stroke. Int J Clin Pharmacol Ther 53:9–12

    Article  PubMed  Google Scholar 

  6. Porter RJ, Cereghino JJ, Gladding GD, Hessie BJ, Kupferberg HJ, Scoville B, White BG (1984) Antiepileptic drug development program. Cleve Clin Q 51:293–305

    Article  CAS  PubMed  Google Scholar 

  7. Porter RJ, Penry JK, Lacy JR (1977) Diagnostic and therapeutic reevaluation of patients with intractable epilepsy. Neurology 27:1006–1011.

    Article  CAS  PubMed  Google Scholar 

  8. White HS. Mechanisms of antiepileptic drugs. (1997) In: Epilepsies II, edited by R. Porter and D. Chadwick, pp. 1–30, Butterworth-Heinemann Publ., Boston, MA

    Google Scholar 

  9. Cereghino JJ et al (1974) Carbamazepine for epilepsy. A controlled prospective evaluation. Neurology 24:401–410

    Article  CAS  PubMed  Google Scholar 

  10. Loscher W, Schmidt D Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 52:657–678

Download references

Acknowledgements

The authors are grateful to Drs. John Kehne, Brian Klein and Barbara Sonies for constructive contributions to this paper.

Author information

Authors and Affiliations

  1. Univ. of Pennsylvania, Philadelphia, PA, USA

    Roger J. Porter

  2. USUHS, Bethesda, MD, USA

    Roger J. Porter

  3. Univ. of Pennsylvania, 461 Timber Lane, Devon, PA, 19333, USA

    Roger J. Porter

  4. Kupferberg Associates, LLC, 11430 Strand Drive, Apt 215, Rockville, MD, 20852, USA

    Harvey J. Kupferberg

Authors
  1. Roger J. Porter
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Harvey J. Kupferberg
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Roger J. Porter.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Porter, R.J., Kupferberg, H.J. The Anticonvulsant Screening Program of the National Institute of Neurological Disorders and Stroke, NIH: History and Contributions to Clinical Care in the Twentieth Century and Beyond. Neurochem Res 42, 1889–1893 (2017). https://doi.org/10.1007/s11064-017-2215-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11064-017-2215-y

Keywords

Search

Navigation