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Starch-modified magnetite nanoparticles for impregnation into cartilage

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Abstract

The paper presents preparation and characterization of starch-modified Fe3O4 nanoparticles (NPs) in aqueous dispersion after impregnation into healthy and damaged types of cartilage. We show that starch-modified dispersion has a narrower size distribution than a non‐stabilized one. The average hydrodynamic radius of magnetite NPs in a dispersion used for impregnation into cartilage is (48 ± 1) nm with the width of the distribution from 5 to 200 nm. We investigate stability of aqueous magnetite NPs dispersions during storage and with increase in temperature (up to 70 °C). We find that polydisperse magnetite NPs can penetrate into cartilage and the size and concentration of impregnated particles depend on the organization of the tissue structure. The results confirm the possibility of application of magnetite NPs in diagnostics and laser treatment of degenerative cartilage deceases.

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Acknowledgments

The authors thank Richard Thelen for technical assistance in AFM investigations. The work was supported by Russian Foundation of Basic Research Grants 11-02-92614, 12-08-13166, and 12-02-91326. This work was partly carried out with the support of the Karlsruhe Nano Micro Facility (KNMF, www.kit.edu/knmf), a Helmholtz Research Infrastructure at Karlsruhe Institute of Technology (KIT, www.kit.edu).

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Authors and Affiliations

  1. Institute on Laser & Information Technologies, Russian Academy of Sciences, Troitsk, 142190, Russia

    Yulia M. Soshnikova, Olga I. Baum & Emil N. Sobol

  2. Department of Chemistry, Lomonosov Moscow State University, Moscow, 119992, Russia

    Yulia M. Soshnikova, Mariya V. Obrezkova & Valeriy V. Lunin

  3. A.N. Bach Institute of Biochemistry, Moscow, 119071, Russia

    Svetlana G. Roman & Natalia A. Chebotareva

  4. National Centre for Macromolecular Hydrodynamics, University of Nottingham, Nottingham, LE12 5RD, UK

    Richard B. Gillis & Stephen E. Harding

Authors
  1. Yulia M. Soshnikova
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  2. Svetlana G. Roman
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  3. Natalia A. Chebotareva
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  4. Olga I. Baum
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  5. Mariya V. Obrezkova
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  6. Richard B. Gillis
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  7. Stephen E. Harding
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  8. Emil N. Sobol
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  9. Valeriy V. Lunin
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Corresponding author

Correspondence to Yulia M. Soshnikova.

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Soshnikova, Y.M., Roman, S.G., Chebotareva, N.A. et al. Starch-modified magnetite nanoparticles for impregnation into cartilage. J Nanopart Res 15, 2092 (2013). https://doi.org/10.1007/s11051-013-2092-5

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