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Mangiferin attenuates cisplatin-induced acute kidney injury in rats mediating modulation of MAPK pathway

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Cisplatin has been confined due to the reported cases of nephrotoxicity. In the present study, an active xanthone, Mangiferin (from Mangifera indica) was investigated for its defensive role in cisplatin-induced nephrotoxicity. Male wistar albino rats were divided into six groups i.e., group 1 (normal); group 2 (cisplatin control); group 3, 4, and 5 (mangiferin 10, 20, and 40 mg/kg, i.p.); and per se (40 mg/kg; i.p.). The treatment was given for 10 days. On day 7, single dose of cisplatin 8 mg/kg i.p. was administered to induce nephrotoxicity in all groups except normal and per se. On day 11, animals were anesthetized, blood was taken from heart and serum was separated. Thereafter, rats were sacrificed and kidneys were isolated and preserved for histopathological, ultrastructural, immunohistochemical, and western blot analysis. Cisplatin control group showed significant impairment in renal function due to increased inflammation and oxidative stress which was also confirmed by histopathology and MAPK pathway proteins expression. However, pretreatment with mangiferin 20 and 40 mg/kg significantly reversed the renal function along with the structural changes and the levels of antioxidants. Mangiferin treatment attenuated DNA damage and apoptotic pathway.

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Acknowledgements

We are thankful to all technical staff for their assistance during the study.

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  1. Anil Kumar Sahu and Vipin Kumar Verma have contributed equally to this work.

Authors and Affiliations

  1. Department of Pharmacology, Cardiovascular Research Laboratory, All India Institute of Medical Sciences, New Delhi, 110029, India

    Anil Kumar Sahu, Vipin Kumar Verma, Ekta Mutneja, Salma Malik, Dharamvir Singh Arya & Jagriti Bhatia

  2. Department of Anatomy, All India Institute of Medical Sciences, New Delhi, 110029, India

    Tapas Chandra Nag

  3. Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India

    Amit Kumar Dinda

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Sahu, A.K., Verma, V.K., Mutneja, E. et al. Mangiferin attenuates cisplatin-induced acute kidney injury in rats mediating modulation of MAPK pathway. Mol Cell Biochem 452, 141–152 (2019). https://doi.org/10.1007/s11010-018-3420-y

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